The role of multiple high-risk human papillomavirus infections for cervical biopsies and findings in colposcopic procedures
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info:eu-repo/semantics/openAccessAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/Tarih
2023Üst veri
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Akış, S., Öztürk, U. K., Keleş, E., Alınca, C. M., Kabaca, C. ve Api, M. (2023). The role of multiple high-risk human papillomavirus infections for cervical biopsies and findings in colposcopic procedures. Journal of the Turkish German Gynecology Association, 24(2), 101-108. https://dx.doi.org/10.4274/jtgga.galenos.2023.2022-8-10Özet
Objective: The clinical outcome of high-risk HPV (hr-HPV) infection varies according to genotype(s). Patients may harbor either one single hr-HPV (s-HPV) or multiple HPV (m-HPV) genotypes. Recently, the relationship between m-HPV infections and high-grade dysplasia has been investigated, and controversial results have been obtained. Therefore, the clinical significance of m-HPV is not clear. This study aimed to evaluate which group is associated with higher grade dysplasia by analyzing colposcopic punch biopsies. Material and Methods: A total of 690 patients who were scheduled for a diagnostic excisional procedure between April 2016 and January 2019 due to the detection of high-grade cervical intraepithelial neoplasia (CIN 2/3) in colposcopy were included. Patients who were not scheduled for colposcopic examination or cervical punch biopsy, or who were scheduled for an excisional procedure due to smear-biopsy incompatibility or persistent low-grade dysplasia were excluded. Patients with a negative HPV test and an unknown HPV genotype were also excluded. Results: Among the patients scheduled for excision (n=404), 74.5% had a s-HPV and 25.5% had a m-HPV infection. The proportion of CIN 1, 2 and 3 per patient in the m-HPV group was significantly higher than the s-HPV group (p=0.017). When this analysis was made for the number of CIN 2+3 per patient in the s-HPV and m-HPV groups, it was 1.29 (389/301) and 1.36 (140/103), respectively, and no difference was found (p=0.491). Conclusion: Patients in the m-HPV group, who underwent more colposcopic cervical biopsies, had higher numbers of CIN lesions, regardless of age and cytology results.
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Q3Kaynak
Journal of the Turkish German Gynecology AssociationCilt
24Sayı
2Bağlantı
https://dx.doi.org/10.4274/jtgga.galenos.2023.2022-8-10https://hdl.handle.net/20.500.12511/11187