dc.contributor.author | Macit, Çağlar | |
dc.contributor.author | Özbeyli, Dilek | |
dc.contributor.author | Çevik, Özge | |
dc.contributor.author | Çetin, Melisa | |
dc.contributor.author | Şener, Göksel | |
dc.contributor.author | Özkan, Sevil | |
dc.date.accessioned | 2023-06-12T07:23:11Z | |
dc.date.available | 2023-06-12T07:23:11Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Macit, Ç., Özbeyli, D., Çevik, Ö., Çetin, M., Şener, G. ve Özkan, S. (2023). Protective effects of momordica charantia (Bitter Melon) against metho-trexate-induced kidney damage. Current Drug Therapy, 18(3), 231-236. https://doi.org/10.2174/1574885518666230112110246 | en_US |
dc.identifier.issn | 1574-8855 | |
dc.identifier.uri | https://doi.org/10.2174/1574885518666230112110246 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/11064 | |
dc.description.abstract | Background: Methotrexate is a cytotoxic chemotherapeutic agent that has severe side ef-fects, such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been shown to have antioxidant, antidiabetic, and anti-inflammatory properties. Methods: 24 Sprague Dawley male rats were divided into three experimental groups (8 rats in each): Control (C); Methotrexate (MTX); and Methotrexate plus Momordica charantia (MTX+MC). All rats were fed ad libitum and tap water. Methotrexate was administered at 20 mg/kg intraperitoneally as a single dose. In the MTX+MC group, MC was administered at a dose of 50mg/kg for 5 days orally. At the end of the 5th day, the rats were decapitated and kidney samples were taken to analyze glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and caspase-3 activity. Data was analyzed with GraphPad Prism 5.0. Results: Findings showed that while there was a significant increase in MDA, MPO, 8-OHdG levels, and an essential reduction in GSH levels in the MTX-treated group when compared with the control group, bitter melon treatment significantly reversed MDA, MPO, and 8-OHdG levels (p< 0.001). GSH level elevation was observed in the MTX-MC group when compared to the MTX-treated group (p< 0.001). Conclusion: This study showed that bitter melon is thought to have a protective effect against kidney damage caused by methotrexate. With future studies, we believe that the use of bitter melon extract as a protective agent in kidney damage caused by drug-induced oxidative damage will bring an innova-tive approach to treatment. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Bentham Science Publishers | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Kidney | en_US |
dc.subject | Methotrexate | en_US |
dc.subject | Momordica Charantia | en_US |
dc.subject | Nephrotoxicity | en_US |
dc.subject | Oxidative Damage | en_US |
dc.subject | Protective Effect | en_US |
dc.title | Protective effects of momordica charantia (Bitter Melon) against metho-trexate-induced kidney damage | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Current Drug Therapy | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-5532-2395 | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 231 | en_US |
dc.identifier.endpage | 236 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.2174/1574885518666230112110246 | en_US |
dc.institutionauthor | Macit, Çağlar | |
dc.identifier.scopus | 2-s2.0-85160608207 | en_US |
dc.identifier.scopusquality | Q3 | en_US |