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Toplam kayıt 10, listelenen: 1-10
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
(Elsevier Sciences Bv, 2017)
Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ...
Ischemic post-conditioning induces post-stroke neuroprotection via Hsp70-mediated proteasome inhibition and facilitates neural progenitor cell transplantation
(Humana Press Inc, 2017)
In view of the failure of pharmacological therapies, alternative strategies promoting post-stroke brain repair are needed. Post-conditioning is a potentially promising therapeutic strategy, which induces acute neuroprotection ...
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
(Academic Press Inc Elsevier Science, 2017)
Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ...
Poloxamer P85 increases anticancer activity of schiff base against prostate cancer in vitro and in vivo
(Lippincott Williams and Wilkins, 2017)
Prostate cancer is the second most common cancer among men and the leading cause of death after lung cancer. Development of hormone-refractory disease is a crucial step for prostate cancer progression for which an effective ...
Anticonvulsant activity of resveratrol-loaded liposomes in vivo
(Pergamon-Elsevier Science Ltd, 2017)
Resveratrol (3,5,4'-stilbenetriol), a natural polyphenol produced by various plants, has attracted attention over the past decade because of its multiple beneficial properties, including anti-inflammatory, anti-oxidant and ...
The neuroprotective effect of focused ultrasound: New perspectives on an old tool
(Pergamon-Elsevier Science Ltd., 2017)
Introduction Transcranial focused ultrasound (tFUS) is a novel technique that can noninvasively modulate the cortical function. Moreover, there are rapidly replicating evidence suggesting the role of tFUS for targeted ...
Effects of erythropoietin on spontaneous and oxytocin induced myometrial contractions in the nonpregnant rat
(Verduci Publisher, 2017)
OBJECTIVE: Erythropoietin (EPO) is a glycoprotein hormone that regulates erythropoiesis. EPO activity has also been detected in a variety of tissue including the nervous system, and female and male reproductive organs. It ...
Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
(Medknow Publications & Media Pvt Ltd., 2017)
Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after ...
Toward a personalized medicine in wake-up stroke?
(Bentham Science Publishers Ltd., 2017)
Ischemic stroke (IS), especially wake-up stroke, is reported to occur with a maximal peak in the morning hoursand usually associated with worse clinical outcome [1-3].Many proposed mechanisms are reported to be responsiblefor ...
Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease?
(Wiley, 2017)
Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms ...