Assessment of retinal thickness as a marker of brain masculinization in children with congenital adrenal hyperplasia: A pilot study

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dc.authorid0000-0003-4930-8447
dc.contributor.authorÖnal, Hasan
dc.contributor.authorKutlu, Esra
dc.contributor.authorAydın, Banu
dc.contributor.authorErsen, Atilla
dc.contributor.authorTopal, Neval
dc.contributor.authorAdal, Erdal
dc.contributor.authorGüneş, Hatice
dc.contributor.authorDoktur, Hilal
dc.contributor.authorTanıdır, Canan
dc.contributor.authorPirhan, Dilara
dc.contributor.authorSayın, Nihat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:24Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:24Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractTo investigate the relationship between brain masculinization and retinal thickness in children with congenital adrenal hyperplasia (CAH). Forty-five patients with CAH aged between 4 and 18 years and 30 age-matched healthy controls were included in this prospective study. Macular area was examined with optical coherence tomography (OCT); central subfield thickness (CST), cube volume (CV) and macular retinal thickness (MT) were measured in each subject. A gender identity questionnaire (GIQ) was used for the evaluation of gender happiness index. Girls with CAH had a higher CV (p = 0.002) and MT (p = 0.003) than healthy girls. No significant difference was found between boys with CAH and healthy boys regarding the retinal thickness measurements. Mean CST, CV and MT were significantly higher in boys than in girls in the control group (p = 0.013, p < 0.001, respectively), but there was no significant difference in those parameters between girls and boys with CAH. The gender happiness index was not different between healthy boys and boys with CAH, but was significantly lower in girls with CAH than healthy girls (p = 0.01). As retina is part of the brain, our finding appears to be a morphological evidence of the excess androgen exposure on brain structures in girls with CAH. In addition, we suggest using retinal thickness measurements as a marker of prenatal excess androgen exposure in future studies.
dc.identifier.citationÖnal, H., Kutlu, E., Aydın, B., Ersen, A., Topal, N., Adal, E. ... Sayın, N. (2019). Assessment of retinal thickness as a marker of brain masculinization in children with congenital adrenal hyperplasia: A pilot study. Journal of Pediatric Endocrinology and Metabolism, 32(7), 683-687. https://dx.doi.org/10.1515/jpem-2018-0397
dc.identifier.doi10.1515/jpem-2018-0397
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue7
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1398
dc.identifier.urihttps://dx.doi.org/10.1515/jpem-2018-0397
dc.identifier.volume32
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDe Gruyter
dc.relation.ispartofJournal of Pediatric Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCongenital Adrenal Hyperplasia
dc.subjectDisorders of Sex Development
dc.subjectGender Dysphoria
dc.subjectRetinal Thickness
dc.titleAssessment of retinal thickness as a marker of brain masculinization in children with congenital adrenal hyperplasia: A pilot study
dc.typeArticle

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