Factors affecting survival in retroperitoneal sarcomas treated with upfront surgery: A real-world study by Turkish Oncology Group

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dc.authorid0000-0002-0077-6971
dc.contributor.authorAkagündüz, Baran
dc.contributor.authorAkın Telli, Tuğba
dc.contributor.authorYıldırım, Hasan Çağrı
dc.contributor.authorGöksu, Sema Sezgin
dc.contributor.authorDemir, Nazan
dc.contributor.authorHafızoğlu, Emre
dc.contributor.authorÖzer, Muhammet
dc.contributor.authorÇevik, Gökçen Tuğba
dc.contributor.authorSakin, Abdullah
dc.contributor.authorGöktaş Aydın, Sabin
dc.contributor.authorŞengül Samancı, Nilay
dc.contributor.authorÖzyurt, Neslihan
dc.contributor.authorAtçı, Muhammed Mustafa
dc.contributor.authorAyhan, Murat
dc.contributor.authorTuran, Merve
dc.contributor.authorSarıyar, Nisanur
dc.contributor.authorKaraçin, Cengiz
dc.contributor.authorKılıçkap, Saadettin
dc.contributor.authorPaydaş, Semra
dc.contributor.authorDoğan, Mutlu
dc.date.accessioned2021-05-28T08:04:44Z
dc.date.available2021-05-28T08:04:44Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractRetroperitoneal sarcomas (RPS) account for approximately 15% of all soft tissue sarcomas (STS) and encompass a heterogeneous group of tumors with limited multimodality treatment options. Surgical resection with negative margins remains the standard primary treatment for patients with localized RPS. In this multicenter study, we aimed to demonstrate the real-world data on factors affecting survival in RPS treated with upfront surgery. We included a total of 197 patients who underwent curative-intent resection of a primary non-metastatic RPS between 2000-2020 at ten experienced medical oncology departments in Turkey. The median follow-up was 33 months. The median age of patients was 53 years, 57.4% of patients were female. Univariate analysis revealed that; tumor size, grade, necrosis, resection margin status, were factors affecting recurrence-free survival (RFS) (p= 0.002, p= 0.044, p= 0,024, p= 0.003 respectively). Age, tumor size, stage, resection margin status were factors affecting overall survival (OS) (p= 0.038, p= 0.001, p= 0.032, p< 0.001, respectively). In multivariate analysis, tumor size and resection margin status were independent factors affecting RFS and OS (all p-values < 0.05). Our study demonstrated that tumor size, and resection margin status were the main factors affecting survival in resected RFS. In comparison, adjuvant chemotherapy (CT), radiotherapy (RT), or multimodality treatment did not show OS and RFS advantages. We believe that advances in the molecular characterization of these tumors might help clinicians to detect the best candidates for adjuvant therapies in RPS.
dc.identifier.citationAkagündüz, B., Akın Telli, T., Yıldırım, H. Ç., Göksu, S. S., Demir, N., Hafızoğlu, E. ... Doğan, M. (2021). Factors affecting survival in retroperitoneal sarcomas treated with upfront surgery: A real-world study by Turkish Oncology Group. UHOD - Uluslararası Hematoloji-Onkoloji Dergisi, 31(2), 92-98. https://dx.doi.org/10.4999/uhod.215190
dc.identifier.doi10.4999/uhod.215190
dc.identifier.endpage98
dc.identifier.issn1306-133X
dc.identifier.issue2
dc.identifier.scopusqualityQ4
dc.identifier.startpage92
dc.identifier.urihttps://dx.doi.org/10.4999/uhod.215190
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6956
dc.identifier.volume31
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAkad Doktorlar Yayinevi
dc.relation.ispartofUHOD - Uluslararası Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSurvival
dc.subjectRetroperitoneal Sarcoma
dc.subjectAdjuvant Chemotherapy
dc.subjectAdjuvant Radiotherapy
dc.subjectSurgery
dc.titleFactors affecting survival in retroperitoneal sarcomas treated with upfront surgery: A real-world study by Turkish Oncology Group
dc.typeArticle

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