The rhythmicity of life: A review of the circadian clocks

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dc.authorid0000-0003-2143-5268
dc.contributor.authorAçıkgöz, Eda
dc.contributor.authorKarahüseyinoğlu, Serçin
dc.contributor.authorAyla, Şule
dc.contributor.authorÖktem, Gülperi
dc.date.accessioned2022-04-26T06:33:13Z
dc.date.available2022-04-26T06:33:13Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractPhysiology of the mammalian body has been adapted to diurnal cycles of around 24 h, an evolutionary situation that affects a wide spectrum of biological events including sleep-to-wake transitions, feeding/fasting, body temperature, and hormonal regulations. The patterns of the diurnal cycle occur due to rhythmic oscillations that arise from the suprachiasmatic nucleus of hypothalamus, which also can be defined as the pacemaker of the system. The clock can be defined as a molecular machinery driven by the core clock genes that encode clock proteins in a rhythmic oscillatory fashion maintained by the light/dark cycles of the environment. Although the well-established knowledge refers to the function of the circadian rhythm as maintenance of the normal physiology, growing evidence shows that disruptions in the system usually caused by genetic and/or epigenetic misregulations may have a direct effect to lead major pathological conditions, such as carcinogenesis. This review outlines the main molecular aspects of circadian physiology, and reveals the reasons for and results of the circadian disruptions at different levels. In spite of the fact that more proof is needed for a direct correlation between circadian disruptions and oncogenesis and other pathological events, data obtained from current research supports the role of circadian rhythms in malfunctioning of the normal cellular metabolism.
dc.identifier.citationAçıkgöz, E., Karahüseyinoğlu, S., Ayla, Ş. ve Öktem, G. (2021). The rhythmicity of life: A review of the circadian clocks. Critical Reviews in Oncogenesis, 26(4), 37-53. https://doi.org/10.1615/CritRevOncog.2022042786
dc.identifier.doi10.1615/CritRevOncog.2022042786
dc.identifier.endpage53
dc.identifier.issn0893-9675
dc.identifier.issue4
dc.identifier.pmid35381146
dc.identifier.scopus2-s2.0-85127670678
dc.identifier.scopusqualityQ3
dc.identifier.startpage37
dc.identifier.urihttps://doi.org/10.1615/CritRevOncog.2022042786
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9377
dc.identifier.volume26
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAyla, Şule
dc.language.isoen
dc.publisherBegell House Inc.
dc.relation.ispartofCritical Reviews in Oncogenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarcinogenesis
dc.subjectChronotherapy
dc.subjectCircadian Regulation
dc.subjectEpigenetics
dc.subjectGenetics
dc.titleThe rhythmicity of life: A review of the circadian clocks
dc.typeArticle

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