The diagnostic role of "acceleration time" measurement in patients with classical low flow low gradient aortic stenosis with reduced left ventricular ejection fraction

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dc.authorid0000-0002-4607-5724
dc.contributor.authorMemiç Sancar, Kadriye
dc.contributor.authorBabur Güler, Gamze
dc.contributor.authorTanboğa, Halil İbrahim
dc.contributor.authorTürkvatan Cansever, Aysel
dc.contributor.authorDemir, Ali Rıza
dc.contributor.authorGüler, Arda
dc.contributor.authorTekin, Meltem
dc.contributor.authorUygur, Begüm
dc.contributor.authorBirant, Ali
dc.contributor.authorAvcı, Yalçın
dc.contributor.authorGüler, Ekrem
dc.contributor.authorErtürk, Mehmet
dc.date.accessioned2023-09-14T09:20:50Z
dc.date.available2023-09-14T09:20:50Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractPurpose In our study, we aimed to assess the role of acceleration time (AT), ejection time (ET), and AT/ET ratio to distinguish between true and pseudo severe AS in patients with classical low flow-low gradient (LF-LG) aortic stenosis (AS) with reduced left ventricular ejection fraction (LVEF). Methods Sixty-seven classical LF-LG AS with reduced LVEF patients who underwent dobutamine stress echocardiography (DSE) were included in the study. According to DSE results, all patients were divided into two groups; true AS and pseudo severe AS. Aortic valve calcium score was measured in patients with inconclusive DSE results. AT and other ejection dynamics (ET and AT/ET) were calculated by taking baseline echocardiographic records into account for all patients. The predictive power of AT and other ejection dynamics were evaluated to estimate true and pseudo severe AS. Results According to DSE results, out of 67 patients, 44 (65.7%) was diagnosed as true severe AS. There was a statistically significant relation between baseline AT and true AS [adjusted OR 4.47 (95% CI 1.93-10.4), p = 0.001]. The best cutoff value of AT was measured as 100 msec according to the Youden index. This value had a sensitivity value of 77%, specificity value of 87%, positive predictive value of 92%, and a negative predictive value of 67%. Conclusion The measurement of AT can predict the DSE outcome and can be used for diagnostic purposes to distinguish between true and pseudo severe AS in classical LF-LG AS patients with reduced LVEF.
dc.identifier.citationMemiç Sancar, K., Babur Güler, G., Tanboğa, H. İ., Türkvatan Cansever, A., Demir, A. R., Güler, A. ... Ertürk, M. (2023). The diagnostic role of "acceleration time" measurement in patients with classical low flow low gradient aortic stenosis with reduced left ventricular ejection fraction. International Journal of Cardiovascular Imaging, 39(3), 481-489. https://dx.doi.org/10.1007/s10554-022-02745-2
dc.identifier.doi10.1007/s10554-022-02745-2
dc.identifier.endpage489
dc.identifier.issn1569-5794
dc.identifier.issn1875-8312
dc.identifier.issue3
dc.identifier.pmid36394680
dc.identifier.scopus2-s2.0-85146249262
dc.identifier.scopusqualityQ2
dc.identifier.startpage481
dc.identifier.urihttps://dx.doi.org/10.1007/s10554-022-02745-2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11431
dc.identifier.volume39
dc.identifier.wos000884941100002en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüler, Ekrem
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Journal of Cardiovascular Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVentricular Ejection Fraction
dc.subjectAcceleration Time
dc.subjectGradient Aortic Stenosis
dc.subjectMeasurement in Patients
dc.titleThe diagnostic role of "acceleration time" measurement in patients with classical low flow low gradient aortic stenosis with reduced left ventricular ejection fraction
dc.typeArticle

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