Elevated 1-h post-load plasma glucose levels in normal glucose tolerance children with obesity is associated with early carotid atherosclerosis
| dc.authorid | 0000-0002-8968-4079 | |
| dc.authorid | 0000-0002-1044-6888 | |
| dc.contributor.author | Kılınç, Suna | |
| dc.contributor.author | Demirtaş, Tuna | |
| dc.contributor.author | Atay, Enver | |
| dc.contributor.author | Ceran, Ömer | |
| dc.contributor.author | Atay, Zeynep | |
| dc.date.accessioned | 2020-07-13T06:05:31Z | |
| dc.date.available | 2020-07-13T06:05:31Z | |
| dc.date.issued | 2020 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | |
| dc.description.abstract | Context: Evidence suggests thatthe 1-h post-load plasma glucose (1-h PG) ?155 mg/dL during an oral glucose tolerance test(OGTT) predicts development oftype 2 diabetes (T2DM) and associated complications, among adults with normal glucose tolerance (NGT), but relevant data on children is scarce. Objectives: To investigate whether NGT children with obesity whose 1-h PG is ?155 mg/dL have an increased carotid intima-media thickness (IMT) and exhibit non-alcoholic fatty liver disease (NAFLD) diagnosed by ultrasonography, as compared with NGT subjects with 1-h PG <155 mg/dL and impaired glucose tolerance (IGT). Methods: Cardio-metabolic profile, OGTT, measurements of carotid IMT and liver ultrasonography were analyzed in 171 non-diabetic children with obesity. Subjects were divided into 3 groups: NGT subjects with a 1-h PG <155 mg/dL, NGT subjects with a 1-h PG ?155 mg/dL, and IGT subjects. Results: As compared with NGT individuals with a 1-h PG <155 mg/dL, NGT individuals with a 1-h PG ?155 mg/dL exhibited higher carotid IMT (0.75 ± 0.15 mm vs. 0.68 ± 0.15 mm; p < 0.05). No significant differences were observed in carotid IMT between IGT and NGT subjects with a 1-h PG ?155 mg/dL (0.75 ± 0.18 mm vs 0.75 ± 0.15 mm; p > 0.05). Of the three glycemic parameters, 1-h and 2-h PG, but not fasting glucose, were significantly correlated with carotid IMT. There were no significant differences for increased risk of having NAFLD between the three groups. Conclusions: These data suggest that a value of 1-h PG ?155 mg/dL in children and adolescents with obesity is as important as IGT with respect to cardiovascular risks. | |
| dc.identifier.citation | Kılınç, S., Demirtaş, T., Atay, E., Ceran, Ö. ve Atay, Z. (2020). Elevated 1-h post-load plasma glucose levels in normal glucose tolerance children with obesity is associated with early carotid atherosclerosis. Obesity Research & Clinical Practice, 14(2), 136-141. https://dx.doi.org/10.1016/j.orcp.2020.02.001 | |
| dc.identifier.doi | 10.1016/j.orcp.2020.02.001 | |
| dc.identifier.endpage | 141 | |
| dc.identifier.issn | 1871-403X | |
| dc.identifier.issn | 1878-0318 | |
| dc.identifier.issue | 2 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 136 | |
| dc.identifier.uri | https://dx.doi.org/10.1016/j.orcp.2020.02.001 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/5459 | |
| dc.identifier.volume | 14 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.relation.ispartof | Obesity Research & Clinical Practice | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Obesity | |
| dc.subject | 1-H Post-Load Hyperglycemia | |
| dc.subject | Atherosclerosis | |
| dc.subject | Non-Alcoholic Fatty Liver Disease | |
| dc.title | Elevated 1-h post-load plasma glucose levels in normal glucose tolerance children with obesity is associated with early carotid atherosclerosis | |
| dc.type | Article |
