Evaluation of the correlation between peripheral inflammatory markers and suicide risk in drug-naive first-episode schizophrenia

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dc.contributor.authorYeşilkaya, Ümit Haluk
dc.contributor.authorŞen, Meltem
dc.contributor.authorBalcıoğlu, Yasin Hasan
dc.contributor.authorGökçay, Hasan
dc.contributor.authorÇelikkıran, Pınar
dc.contributor.authorKirlioğlu Balcıoğlu, Simge
dc.contributor.authorKaramustafalioğlu, Nesrin
dc.date.accessioned2025-05-29T17:47:25Z
dc.date.available2025-05-29T17:47:25Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstractIntroduction: Patients with schizophrenia have a higher lifetime prevalence of suicidal behavior (SB) compared to the general population. Therefore, understanding the possible neurobiology of suicide and predicting the risk of suicide in schizophrenia is a solemnly critical issue. Methods: 31 drug-naïve first episode schizophrenia (FES) patients with current SB (FES-S), 69 drug-naive patients with first episode schizophrenia without SB (FES-NS), and 69 drug-naïve non-psychotic patients with current SB (NPS) who were diagnosed according to The Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) participated the study. The control group (HC) consisted of 127 individuals matched with the patients. Symptoms at the time of evaluation were assessed using The Positive and Negative Syndrome Scale (PANSS) and Columbia Suicide Severity Rating Scale (CSSRS). Blood samples were collected from all participants to determine White blood cell (WBC), neutrophil, monocyte, albumin, C-reactive protein (CRP), Lymphocyte, and Platelet levels and to measure this protein ratio. Results: The blood levels of WBC, neutrophil, monocyte, albumin, CRP, and Neutrophil/Albumin Ratio (NAR) were higher in all patient groups compared to HC. CRP/Albumin Ratio (CAR) value was observed to be highest in the NPS group. Monocyte/Lymphocyte Ratio (MLR) value was significantly higher in patients with FES compared to HC. There were no significant differences between the FES-S group and the FES-NS and NPS groups. Conclusion: It can be suggested that although inflammation is not a predictor for suicide attempts in schizophrenia, it is associated with the degree of suicide risk in schizophrenia. In addition, the strong relationship between suicide and psychiatric disorders can be the main reason for high peripheral inflammation levels in suicidal patients.
dc.identifier.citationYeşilkaya, Ü. H., Şen, M., Balcıoğlu, Y. H., Gökçay, H., Çelikkıran, P., Kirlioğlu Balcıoğlu, S. ... Karamustafalioğlu, N. (2024). Evaluation of the correlation between peripheral inflammatory markers and suicide risk in drug-naive first-episode schizophrenia. Noropsikiyatri Arşivi, 61(3), 275-280. http://dx.doi.org/10.29399/npa.28663
dc.identifier.doi10.29399/npa.28663
dc.identifier.endpage280
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue3
dc.identifier.pmid39258132
dc.identifier.scopus2-s2.0-85203156003
dc.identifier.scopusqualityQ3
dc.identifier.startpage275
dc.identifier.urihttp://dx.doi.org/10.29399/npa.28663
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12925
dc.identifier.volume61
dc.identifier.wosWOS:001308043400014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYeşilkaya, Ümit Haluk
dc.institutionauthorid0000-0001-8521-1613
dc.language.isoen
dc.relation.ispartofNoropsikiyatri Arşivi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectC-Reactive Protein/Albumin Ratio
dc.subjectFirst-Episode Schizophrenia
dc.subjectInflammation
dc.subjectNeutrophil/Albumin Ratio
dc.subjectSchizophrenia
dc.subjectSuicide
dc.titleEvaluation of the correlation between peripheral inflammatory markers and suicide risk in drug-naive first-episode schizophrenia
dc.title.alternativeİlaçsız ilk epizot şizofreni hastalarında periferik inflamatuvar belirteçler ile intihar riski arasındaki ilişkinin değerlendirilmesi
dc.typeArticle

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