COVID-19 and SLE: Infection and autoimmunity at its best

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dc.authorid0000-0002-7919-1326
dc.authorid0000-0002-4130-3978
dc.authorid0000-0003-1555-4148
dc.contributor.authorMahroum, Naim
dc.contributor.authorElsalti, Abdulrahman
dc.contributor.authorÖzkan, Mehmet Fatih
dc.contributor.authorShoenfeld, Yehuda
dc.date.accessioned2024-01-11T10:47:01Z
dc.date.available2024-01-11T10:47:01Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractIf one had any doubts before the pandemic regarding the correlation between infections and autoimmunity, COVID-19 left us fascinated on the strong bond between the two entities. The immune and autoimmune reactions seen in patients infected with SARS-CoV-2 have served as a base for this assumption. Later on, the use of immunosuppressants such as systemic glucocorticoids, among other biological agents, turned this assumption to a fact. This was no different when it comes to the vaccines against COVID-19. Through several postulated mechanisms these vaccines, although generally considered safe, are thought to have the potential to result in autoimmune reactions making them not more innocent than the infection itself. When systemic lupus erythematous (SLE) is viewed as a classical autoimmune multisystemic disorder, the connection with SARS-CoV-2 infection and COVID-19 vaccination is of extreme importance. This is because early reports during the pandemic have shown increased rates of SARS-CoV-2 infection among patients known previously to have SLE and much more interestingly, cases of new-onset SLE after COVID-19 have been documented in the literature. Subsequently vaccines against COVID-19, those mRNA-based and adenovirus-vector based, were reported to induce new SLE cases, trigger immune thrombocytopenia or lupus nephritis, two common presentations of SLE, or exacerbate flares. In our paper, we concluded various aspects of available and recent data regarding SLE and COVID-19 as both an infection and vaccination.
dc.identifier.citationMahroum, N., Elsalti, A., Özkan, M. F. ve Shoenfeld, Y. (2023). COVID-19 and SLE: Infection and autoimmunity at its best. Lupus, 32(14), 1591-1597. https://dx.doi.org/10.1177/09612033231213914
dc.identifier.doi10.1177/09612033231213914
dc.identifier.endpage1597
dc.identifier.issn0961-2033
dc.identifier.issn1477-0962
dc.identifier.issue14
dc.identifier.pmid37927085
dc.identifier.scopus2-s2.0-85176092401
dc.identifier.scopusqualityQ2
dc.identifier.startpage1591
dc.identifier.urihttps://dx.doi.org/10.1177/09612033231213914
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12125
dc.identifier.volume32
dc.identifier.wos001096649400001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMahroum, Naim
dc.institutionauthorElsalti, Abdulrahman
dc.institutionauthorÖzkan, Mehmet Fatih
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.relation.ispartofLupusen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutoimmunity
dc.subjectCOVID Vaccine
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectSystemic Lupus Erythematous
dc.titleCOVID-19 and SLE: Infection and autoimmunity at its best
dc.typeReview Article

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