Demographic, clinical and laboratory characteristics of adult-onset minimal change disease in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group

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dc.authorid0000-0003-1185-9737
dc.contributor.authorAydın, Zeki
dc.contributor.authorYılmaz, Mürvet
dc.contributor.authorSipahioğlu, Murat
dc.contributor.authorDervişoğlu, Erkan
dc.contributor.authorAydemir, Nihal
dc.contributor.authorUzun, Sami
dc.contributor.authorİstemihan, Zülal
dc.contributor.authorÜnsal, Oktay
dc.contributor.authorTatar, Erhan
dc.contributor.authorBerktaş, Hacı Bayram
dc.contributor.authorÖzdemir, Arzu
dc.contributor.authorŞumnu, Abdullah
dc.date.accessioned2023-09-21T07:42:24Z
dc.date.available2023-09-21T07:42:24Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose In our study, diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. The data presented are cross-sectional and includes application data for the biopsy period. Results Of 3875 patients, 233 patients with MCD (median age 35.0 years) were included in the study, which constitutes 6.0% of the total glomerulonephritis database. Renal biopsy was performed in 196 (84.1%) patients due to nephrotic syndrome. Median serum creatinine was 0.7 (0.6-1.0) mg/dl, mean eGFR was 104 +/- 33 ml/min/1.73 m(2) and median proteinuria 6000 mg/day. The number of patients under the age of 40 years was 139 (59.7%) (Group A), and the number of patients aged 40 years and over was 94 (40.3%) (Group B). Compared to Group A, global sclerotic glomeruli (24 vs. 43, p < 0.001) interstitial inflammation (15 vs. 34, p < 0.001), interstitial fibrosis (20 vs. 31, p = 0.001, vascular changes (10 vs. 25, p < 0.001) and tubular atrophy (18 vs. 30, p < 0.001) were found to be significantly higher in Group B. There was no difference in immunofluorescent staining properties between the two groups. Conclusion Our data are generally compatible with the literature. Chronic histopathological changes were more common in patients aged 40 years and older than younger patients. Studies investigating the effects of these different features on renal survival are needed.
dc.identifier.citationAydın, Z., Yılmaz, M., Sipahioğlu, M., Dervişoğlu, E., Aydemir, N., Uzun, S. ... Şumnu, A. (2023). Demographic, clinical and laboratory characteristics of adult-onset minimal change disease in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group. International Urology and Nephrology, 55(4), 975-982. https://doi.org/10.1007/s11255-022-03382-3
dc.identifier.doi10.1007/s11255-022-03382-3
dc.identifier.endpage982
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue4
dc.identifier.pmid36178610
dc.identifier.scopus2-s2.0-85139246483
dc.identifier.scopusqualityQ2
dc.identifier.startpage975
dc.identifier.urihttps://doi.org/10.1007/s11255-022-03382-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11476
dc.identifier.volume55
dc.identifier.wos000862187700003en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞumnu, Abdullah
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPrimary Glomerular Diseases
dc.subjectMinimal Change Disease
dc.subjectNephrotic Syndrome
dc.titleDemographic, clinical and laboratory characteristics of adult-onset minimal change disease in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group
dc.typeArticle

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