Effects of systemic erythropoietin treatment and heterogeneous xenograft in combination on bone regeneration of a critical-size defect in an experimental model

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dc.authorid0000-0001-6494-8923
dc.contributor.authorDiker, Nurettin Yağmur
dc.contributor.authorSarıcan, Hande
dc.contributor.authorCumbul, Alev
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:03Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:03Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000449077700008
dc.descriptionPubMed ID: 30301650
dc.description.abstractThe aim of the present study was to evaluate the effects of systemic EPO treatment alone or in combination with xenogenic bone graft augmentation on bone regeneration. Eleven adult male Sprague-Dawley rats were used in the present study. Rats were subjected to bilateral 5 mm critical size bone defects on the parietal bones under general anaesthesia. Right parietal bone defects were augmented with xenogenic bone graft and left parietal bone defect was left empty. Rats were randomly assigned for one of the two groups. One group of rats received (i) vehicle (n = 6) and other group received (ii) EPO (500IU kg/day) (n = 5). EPO treatment was continued for 28 days. Vascularization was analysed by immunohistochemical staining of CD31 (PECAM-1) and new bone formation was histomorphometrically evaluated. Xenogenic graft augmentation enhanced bone formation and vascularization significantly in either vehicle or EPO treated groups (p <0.05). Histomorphometric results of angiogenesis was similar in the EPO treated group and the control group. However, angiogenesis was significantly higher in the combination of systemic EPO treatment with graft augmentation than graft augmentation alone (p <0.01). Graft augmentation for treatment of critical size bone defects seems essential for proper bone healing. Results of the present study suggest that EPO potentiates the regenerative processes of augmented bone defects.
dc.identifier.citationDiker, N., Sarıcan, H., Cumbul, A. ve Kılıç, E. (2018). Effects of systemic erythropoietin treatment and heterogeneous xenograft in combination on bone regeneration of a critical-size defect in an experimental model. Journal of Cranio-Maxillofacial Surgery, 46(11), 1919-1923. https://dx.doi.org/10.1016/j.jcms.2018.09.015
dc.identifier.doi10.1016/j.jcms.2018.09.015
dc.identifier.endpage1923
dc.identifier.issn1010-5182
dc.identifier.issn1878-4119
dc.identifier.issue11
dc.identifier.scopusqualityN/A
dc.identifier.startpage1919
dc.identifier.urihttps://dx.doi.org/10.1016/j.jcms.2018.09.015
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1865
dc.identifier.volume46
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectErythropoietin
dc.subjectAngiogenesis
dc.subjectBone Healing
dc.subjectCalvarial Defect
dc.subjectXenograft
dc.titleEffects of systemic erythropoietin treatment and heterogeneous xenograft in combination on bone regeneration of a critical-size defect in an experimental model
dc.typeArticle

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