Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker

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dc.authorid0000-0002-3887-4569
dc.contributor.authorBabademez, Mehmet Ali
dc.contributor.authorGül, Fatih
dc.contributor.authorKale, Hayati
dc.contributor.authorMüderris, Togay
dc.contributor.authorBayazıt, Yıldırım
dc.contributor.authorErgin, Merve
dc.contributor.authorErel, Özcan
dc.contributor.authorKiriş, Muzaffer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:25Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:25Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000396449600005
dc.descriptionPubMed ID: 27383276
dc.description.abstractObjectives: The aim of this study was to investigate the relationship between Bell's palsy and a novel oxidative stress parameter, thiol/disulphide homeostasis. Design: A prospective study evaluating oxidative stress in Bell's palsy. Setting: This research took place in the department of Otorhinolaryngology, Ataturk Training and Research Hospital. Participants: Totally, 77 patients with Bell's palsy and 38 healthy controls were included in this study. Main outcome measures: The blood levels of total and native thiol and disulphide activity were assessed, and their levels were compared in the patients and controls. Results: There were statistically significant differences between the patients and controls regarding thiol/disulphide parameters. The mean native thiol and total thiol were significantly lower and disulphide levels were higher in the Bell's palsy than controls. On binary logistic regression analysis, the created model showed 45.3% variation. The cutoff value was 18.95 for disulphides. Conclusion: Native and total thiol levels were low in the Bell's palsy. This metabolic disturbance may have a role in the pathogenesis of Bell's palsy.
dc.identifier.citationBabademez, M. A., Gül, F., Kale, H., Müderris, T., Bayazıt, Y., Ergin, M. … Kiriş, M. (2017). Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker. Clinical Otolaryngology, 42(2), 239-244. https://dx.doi.org/10.1111/coa.12701
dc.identifier.doi10.1111/coa.12701
dc.identifier.endpage244
dc.identifier.issn1749-4478
dc.identifier.issn1749-4486
dc.identifier.issue2
dc.identifier.scopusqualityQ1
dc.identifier.startpage239
dc.identifier.urihttps://dx.doi.org/10.1111/coa.12701
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2213
dc.identifier.volume42
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectThiol/Disulphide Homeostasis
dc.subjectPathogenetic Marker
dc.subjectBell's Palsy
dc.titleThiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker
dc.typeArticle

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