Reduced power and phase-locking values were accompanied by thalamus, putamen, and hippocampus atrophy in Parkinson's disease with mild cognitive impairment: An event-related oscillation study

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dc.authorid0000-0003-3499-2370
dc.authorid0000-0002-0860-0524
dc.contributor.authorHünerli Gündüz, Duygu
dc.contributor.authorÖzbek İşbitiren, Yağmur
dc.contributor.authorUzunlar, Hakan
dc.contributor.authorÇavuşoğlu, Berrin
dc.contributor.authorDönmez Çolakoğlu, Berril
dc.contributor.authorAda, Emel
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorYener, Görsev
dc.date.accessioned2022-11-25T06:41:57Z
dc.date.available2022-11-25T06:41:57Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Sinirbilim Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractParkinson's disease (PD) is a multifaceted neurodegenerative disorder accompanied by mild cognitive impairment (MCI) as a crucial nonmotor manifestation. Event-related oscillations (EROs) are suggested to reflect cognitive status associated with subcortical structures in neurodegenerative conditions. In this study, 36 individuals with PD-MCI and 32 PD-CN were compared with 60 healthy control (HC) participants using visual EROs by measures of event-related spectral perturbation and inter-trial coherence, along with subcortical gray matter volumes based on the FIRST algorithm. Cross-correlations among electrophysiological, neuropsychological, and structural parameters were investigated exploratively. Both PD-MCI and PD-CN patients had diminished delta and alpha phase-locking than HC, however, electrophysiological abnormalities were more pronounced in PD-MCI over frontal, central, parietal, and temporal locations in almost all frequency bands, accompanied by bilateral thalamus, hippocampus, and right putamen atrophy. PD-CN had lower hippocampal volumes than HC, without exhibiting any subcortical differences from PD-MCI. Lastly, EROs showed low-to-high correlations with structural and neuropsychological measures. These findings may highlight the complex interplay between electrophysiological, neuropsychological, and structural parameters in detected abnormalities of PD-CN and PD-MCI.
dc.description.sponsorshipDokuz Eylül Üniversitesien_US
dc.identifier.citationHünerli Gündüz, D., Özbek İşbitiren, Y., Uzunlar, H., Çavuşoğlu, B., Dönmez Çolakoğlu, B., Ada, E. ... Yener, G. (2023). Reduced power and phase-locking values were accompanied by thalamus, putamen, and hippocampus atrophy in Parkinson's disease with mild cognitive impairment: An event-related oscillation study. Neurobiology of Aging, 121, 88-106. https://doi.org/10.1016/j.neurobiolaging.2022.10.001
dc.identifier.doi10.1016/j.neurobiolaging.2022.10.001
dc.identifier.endpage106
dc.identifier.issn0197-4580
dc.identifier.pmid36395544
dc.identifier.scopus2-s2.0-85142003545
dc.identifier.scopusqualityQ1
dc.identifier.startpage88
dc.identifier.urihttps://doi.org/10.1016/j.neurobiolaging.2022.10.001
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10028
dc.identifier.volume121
dc.identifier.wos000893273800006en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUzunlar, Hakan
dc.institutionauthorGüntekin, Bahar
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofNeurobiology of Agingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBasal Ganglia
dc.subjectEvent-Related
dc.subjectMild Cognitive Impairment
dc.subjectOscillation
dc.subjectParkinson's Disease
dc.subjectPhase
dc.subjectPower
dc.subjectVolumetric MRI
dc.titleReduced power and phase-locking values were accompanied by thalamus, putamen, and hippocampus atrophy in Parkinson's disease with mild cognitive impairment: An event-related oscillation study
dc.typeArticle

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