Antiviral activity of different extracts of standardized propolis preparations against HSV

Basit Öğe Kaydı
dc.authorid0000-0003-4568-4234
dc.contributor.authorDemir, Sevda
dc.contributor.authorAtayoğlu, Ali Timuçin
dc.contributor.authorGaleotti, Fabio
dc.contributor.authorGarzarella, Emanuele U.
dc.contributor.authorZaccaria, Vincenzo
dc.contributor.authorVolpi, Nicola
dc.contributor.authorKaragöz, Ali
dc.contributor.authorŞahin, Fikrettin
dc.date.accessioned2021-06-03T08:26:21Z
dc.date.available2021-06-03T08:26:21Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.description.abstractBackground: Viral infections are among the most common problems in health-care practice. Natural products offer great promise as potentially effective antiviral drugs. Propolis is a honeybee product with biological properties and therapeutic applications. We aimed to investigate the antiviral activity of different extracts of Standardized Propolis Preparations (M.E.D.(R)) with glycol, ethanol, glycerol and soya oil, against herpes simplex type-1 (HSV-1) and type 2 (HSV-2) viruses. Methods: Chemical composition and antiviral activity of each extract were determined. The selective index (SI=CC50/EC50) was determined as a parameter to indicate the in vitro antiviral activity of the extracts compared with acyclovir as the control. Results: SI values of glycol, ethanol, glycerol, soya oil extracts and acyclovir were determined as 6.8, 4.1, 2.2, 3.3 and 6.3 against HSV-1, and as 6.4, 7.7, 1.9, 4.2 and 2.9 against HSV-2, respectively. Glycolic propolis extract was found to possess a greater antiviral activity than acyclovir for both HSV-1 and 2, while glycolic, ethanolic and soya oil preparations were found to have more significant activity than acyclovir for HSV-2. Conclusions: It was determined that standardized propolis preparations have antiviral bioactivity against HSV.
dc.identifier.citationDemir, S., Atayoğlu, A. T., Galeotti, F., Garzarella, E. U., Zaccaria, V., Volpi, N. ... Şahin, F. (2021). Antiviral activity of different extracts of standardized propolis preparations against HSV. Antiviral Therapy, 25(7), 353-363. https://dx.doi.org/10.3851/IMP3383
dc.identifier.doi10.3851/IMP3383
dc.identifier.endpage363
dc.identifier.issn1359-6535
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage353
dc.identifier.urihttps://dx.doi.org/10.3851/IMP3383
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7020
dc.identifier.volume25
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInternational Medical Press Ltd
dc.relation.ispartofAntiviral Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHSV
dc.subjectPreparations Against
dc.subjectStandardized Propolis
dc.titleAntiviral activity of different extracts of standardized propolis preparations against HSV
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Atayoglu-Ali-2021.pdf
Boyut:
715.54 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu