The association of epicardial fat thickness with blunted heart rate recovery in patients with metabolic syndrome

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dc.contributor.authorŞengül, Cihan
dc.contributor.authorDuman, Dursun
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:17Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:17Z
dc.date.issued2011
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000294273000003
dc.descriptionPubMed ID: 21737994
dc.description.abstractEpicardial fat tissue has unique endocrine and paracrine functions that affect the cardiac autonomic system. Epicardial fat thickness (EFT) and blunted heart rate recovery (HRR) are newly identified cardiovascular risk factors in patients with metabolic syndrome (MS). The objective of this study is to evaluate the association between EFT and HRR in patients with MS. Forty patients with MS and 36 healthy controls were included in the study. Echocardiographic EFT and HRR at 1min after exercise termination (HRR-1) are measured and compared between the two groups. HRR-1 equal to or lower than 18 beats is considered as blunted HRR. EFT was increased (7.2 +/- 2 vs. 5.6 +/- 1.8 mm; p = 0.001) and HRR-1 was significantly reduced in patients with MS compared to control group (21 +/- 8 vs. 26 +/- 9; p = 0.006). Among the MS patients, subjects with blunted HRR had increased EFT compared to patients without blunted HRR (8.5 +/- 2.0 vs. 5.9 +/- 1.1 mm, p < 0.001). In multivariate analysis, EFT was the only independent predictor of blunted HRR in patients with MS (95% confidence interval = 1.42-3.87, OR = 2.34, p = 0.001). Furthermore, EFT of equal to or thicker than 5.5 mm was associated with the blunted HRR with 84% sensitivity and 52% specificity (ROC area under curve: 0.84, 95% confidence interval = 0.70-0.96, p < 0.001). In conclusion, EFT is an independent predictor of blunted HRR, a novel cardiovascular risk factor, in patients with MS.
dc.identifier.citationŞengül, C. ve Duman, D. (2011). The association of epicardial fat thickness with blunted heart rate recovery in patients with metabolic syndrome. Tohoku Journal of Experimental Medicine, 224(4), 257-262. https://dx.doi.org/10.1620/tjem.224.257
dc.identifier.doi10.1620/tjem.224.257
dc.identifier.endpage262
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage257
dc.identifier.urihttps://dx.doi.org/10.1620/tjem.224.257
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3841
dc.identifier.volume224
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTohoku University Medical Press
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiac Stress Test
dc.subjectEchocardiography
dc.subjectEpicardial Fat
dc.subjectHeart Rate Recovery
dc.subjectMetabolic Syndrome
dc.titleThe association of epicardial fat thickness with blunted heart rate recovery in patients with metabolic syndrome
dc.typeArticle

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