Usefulness of neutrophil-to-lymphocyte ratio for predicting acute pericarditis outcomes

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dc.authorid0000-0003-1919-3183
dc.authorid0000-0003-0647-4859
dc.authorid0000-0001-5825-8627
dc.authorid0000-0001-8919-614X
dc.contributor.authorYılmaz, Fatih
dc.contributor.authorKızılırmak Yılmaz, Filiz
dc.contributor.authorKaragöz, Ali
dc.contributor.authorYıldırım, Arzu
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorAkbaş, Ravza Betül
dc.contributor.authorEfe, Süleyman Çağan
dc.contributor.authorBarutçu, İrfan
dc.date.accessioned2023-01-18T11:22:21Z
dc.date.available2023-01-18T11:22:21Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground In daily practice, C-reactive protein (CRP) may be used to predict recurrence and treatment response in patients with acute pericarditis; however, the predictive role of CRP might be insufficient for clinical prediction in some patients. In this study, we aimed to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and the composite endpoint of pericarditis recurrence and/or tamponade within 1 year in patients with acute pericarditis. Methods A total of 104 patients diagnosed with acute idiopathic pericarditis (mean age 42.8 +/- 15.2 years, 55.8% male) were included in the study. Physical examination findings of these patients, electrocardiography, echocardiography, chest X-ray and laboratory findings were evaluated and analysed. During the 1-year follow-up, the composite of cardiac tamponade and/or pericarditis recurrence was investigated as the primary endpoint of the study. Results Compared to the group without the composite outcome, the group with the composite outcome had significantly higher rates of moderate and severe pericardial effusion (p < 0.01) and higher white blood cell (WBC) count (p:0.001), platelet count (p = 0.003), NLR (2.14 (1.49-3.02) vs 6.60 (5.50-8.68); p < 0.001) and high-sensitivity C-reactive protein (hs-CRP) (8.01 (5.1-24.5 vs 69.5 (40.8-128); p:0.001). Higher hs-CRP (p < 0.001), WBC (p:0.001), NLR (p < 0.001) and platelets (p:0.02) were associated with pericarditis recurrence. NLR and hs-CRP were independently associated with the composite endpoint (p < 0.001 and p < 0.001, respectively). Conclusion NLR and hs-CRP were found to be independent predictors for the composite endpoint of tamponade and/or recurrence in acute pericarditis patients during the 1-year follow-up. Similar to hs-CRP, NLR may also be used for risk assessment in patients with idiopathic pericarditis.
dc.identifier.citationYılmaz, F., Kızılırmak Yılmaz, F., Karagöz, A., Yıldırım, A., Güneş, H. M., Akbaş, R. B. ... Barutçu, İ. (2022). Usefulness of neutrophil-to-lymphocyte ratio for predicting acute pericarditis outcomes. Acta Cardiologica, 77(5), 422-430. https://dx.doi.org/10.1080/00015385.2021.1951998
dc.identifier.doi10.1080/00015385.2021.1951998
dc.identifier.endpage430
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue5
dc.identifier.pmid34275415
dc.identifier.scopus2-s2.0-85110821244
dc.identifier.scopusqualityQ3
dc.identifier.startpage422
dc.identifier.urihttps://dx.doi.org/10.1080/00015385.2021.1951998
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10330
dc.identifier.volume77
dc.identifier.wos000674800700001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKızılırmak Yılmaz, Filiz
dc.institutionauthorYıldırım, Arzu
dc.institutionauthorGüneş, Hacı Murat
dc.institutionauthorBarutçu, İrfan
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectNeutrophil-to-Lymphocyteratio
dc.subjectAcute Pericarditis
dc.subjectPericarditis Recurrence
dc.subjectTamponade
dc.subjectC-Reactiveprotein
dc.subjectMultivariable
dc.titleUsefulness of neutrophil-to-lymphocyte ratio for predicting acute pericarditis outcomes
dc.typeArticle

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