Edaravone’s hepatoprotective effects against oxidative stress in valproic acid–induced rat model

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dc.contributor.authorHacıhasanoğlu Çakmak, Neziha
dc.contributor.authorYanardağ, Refiye
dc.date.accessioned2025-12-04T17:14:20Z
dc.date.available2025-12-04T17:14:20Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalı
dc.description.abstractIn this experimental study, the effect of edaravone (EDA) on liver damage caused by valproic acid (VPA) was investigated. The antioxidant, oxidative stress, and inflammation indicators such as glutathione (GSH), total lipid (TL), sialic acid (SA), aspartate (AST) and alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) were examined. Male Sprague Dawley rats were used in the experiment and randomly divided into 4 groups. The experiment lasted for 7 days. Group I: control group rats; Group II: rats receiving 0.5 g/kg VPA intraperitoneally daily. Group III: rats receiving 30 mg/kg EDA intraperitoneally daily. Group IV: rats receiving 0.5 g/kg VPA and 30 mg/kg EDA intraperitoneally daily (at the same time). On day 8, all animals were sacrificed under anesthesia, and liver tissues were removed. VPA caused the decreases in GSH, CAT, SOD, GPx, GR, and GST values and the increases in AST, ALT, ALP, GGT, sialic acid, and total lipid values. EDA reversed the in all values. These results suggest that EDA administration potentially reduces liver injury in VPA-induced hepatotoxicity.
dc.identifier.citationHacıhasanoğlu Çakmak, N. ve Yanardağ, R. (2024). Edaravone’s hepatoprotective effects against oxidative stress in valproic acid–induced rat model. Journal of the Turkish Chemical Society, Section A: Chemistry, 11(4), 1629-1640. http://dx.doi.org/10.18596/jotcsa.1548185
dc.identifier.doi10.18596/jotcsa.1548185
dc.identifier.endpage1640
dc.identifier.issn2149-0120
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85211795970
dc.identifier.scopusqualityQ3
dc.identifier.startpage1629
dc.identifier.urihttp://dx.doi.org/10.18596/jotcsa.1548185
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13283
dc.identifier.volume11
dc.indekslendigikaynakScopus
dc.institutionauthorHacıhasanoğlu Çakmak, Neziha
dc.institutionauthorid0000-0002-6183-5015
dc.language.isoen
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant
dc.subjectEdaravone
dc.subjectLiver
dc.subjectOxidative Stress
dc.subjectValproic Acid
dc.titleEdaravone’s hepatoprotective effects against oxidative stress in valproic acid–induced rat model
dc.typeArticle

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