Evaluation of vitamin D status and its correlation with gonadal function in children at mini-puberty

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dc.authorid0000-0002-8968-4079
dc.authorid0000-0002-1044-6888
dc.contributor.authorKılınç, Suna
dc.contributor.authorAtay, Enver
dc.contributor.authorCeran, Ömer
dc.contributor.authorAtay, Zeynep
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:55Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:55Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000453904100014
dc.descriptionPubMed ID: 30229999
dc.description.abstractContext The effects of Vitamin D on reproductive function in adults have gained interest. Studies have demonstrated some associations. Hypothalamic-pituitary-gonadal axis is activated during the first 6 months of life, called as mini-puberty. This HPG activation is important for future gonadal function. There are no data regarding the association of gonadal hormones and 25(OH)D levels at mini-puberty. Demonstration of any association would form the basis for studies that will search for the effects of 25(OH)D on gonadal hormones at mini-puberty. Objective To characterize the associations between 25(OH)D levels and gonadal hormones at mini-puberty. Design Cross-sectional cohort analysis. Patient(s) or other participant(s) A total of 180 (94 boys and 86 girls) healthy appropriate-for-gestational-age neonates were included. Main outcome measure(s) 25(OH)D, LH, FSH, total testosterone, oestradiol, AMH and inhibin B levels were measured at postnatal 30-45 days. All infants were divided into three groups including vitamin D deficiency (<10 ng/mL), vitamin D insufficiency (10-20 ng/mL) and vitamin D sufficiency (>20 ng/mL). Correlations between vitamin D status and reproductive hormones were analysed. Result(s) Total testosterone level was higher (mean: 0.52 +/- 0.32 vs 0.26 +/- 0.2 ng/mL; P: 0.008) and inhibin B was lower in 25(OH)D deficient than sufficient girls (mean: 21.2 +/- 15.71 vs 53.25 +/- 47.25 pg/mL; P: 0.021). Conclusion(s) A modest effect of 25(OH)D was identified on total testosterone and inhibin B in girls at mini-puberty. The 25(OH)D may have an effect on gonadal function during early life. Randomized controlled trials could clarify the importance of vitamin D on gonadal hormones at mini-puberty.
dc.identifier.citationKılınç, S., Atay, E., Ceran, Ö. ve Atay, Z. (2019). Evaluation of vitamin D status and its correlation with gonadal function in children at mini-puberty. Clinical Endocrinology, 90(1), 122-128. https://dx.doi.org/10.1111/cen.13856
dc.identifier.doi10.1111/cen.13856
dc.identifier.endpage128
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage122
dc.identifier.urihttps://dx.doi.org/10.1111/cen.13856
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1815
dc.identifier.volume90
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAMH
dc.subjectInhibin B
dc.subjectMini-Puberty
dc.subjectReproduction
dc.subjectSex Steroids
dc.subjectVitamin D
dc.titleEvaluation of vitamin D status and its correlation with gonadal function in children at mini-puberty
dc.typeArticle

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