Rich club and reward network connectivity as endophenotypes for alcohol dependence: A diffusion tensor imaging study

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dc.contributor.authorZorlu, Nabi
dc.contributor.authorÇapraz, Necip
dc.contributor.authorÖztekin, Esra
dc.contributor.authorBağcı, Başak
dc.contributor.authorDi Biase, Maria A.
dc.contributor.authorZalesky, Andrew
dc.contributor.authorGelal, Fazıl
dc.contributor.authorBora, Emre
dc.contributor.authorDurmaz, Ercan
dc.contributor.authorBeşiroğlu, Lütfullah
dc.contributor.authorSarıciçek, Aybala
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:41Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000458437000010
dc.descriptionPubMed ID: 29280246
dc.description.abstractWe aimed to examine the whole-brain white matter connectivity and local topology of reward system nodes in patients with alcohol use disorder (AUD) and unaffected siblings, relative to healthy comparison individuals. Diffusion-weighted magnetic resonance imaging scans were acquired from 18 patients with AUD, 15 unaffected siblings of AUD patients and 15 healthy controls. Structural networks were examined using network-based statistic and connectomic analysis. Connectomic analysis showed a significant ordered difference in normalized rich club organization (AUD <Siblings <Controls). We also found rank ordered differences (Control> Sibling> AUD) for both nodal clustering coefficient and nodal local efficiency in reward system nodes, particularly left caudate, right putamen and left hippocampus. Network-based statistic analyses showed that AUD group had significantly weaker connectivity than controls in the right hemisphere, mostly in the edges connecting putamen and hippocampus with other brain regions. Our results suggest that reward system network abnormalities, especially in subcortical structures, and impairments in rich-club organization might be related to the familial predisposition for AUD.
dc.description.sponsorshipNHMRC Career Development Fellowship [1047648]; Rotary Health Ian Scott PhD Scholarship in Mental Healthen_US
dc.description.sponsorshipA. Z. was supported by NHMRC Career Development Fellowship (grant 1047648). M. D. B. was supported by the Rotary Health Ian Scott PhD Scholarship in Mental Health.en_US
dc.identifier.citationÇapraz, N., Zorlu, N., Öztekin, E., Bağcı, B., Di Biase, M. A., Zalesky, A. ... Sarıçiçek, A. (2019). Rich club and reward network connectivity as endophenotypes for alcohol dependence: A diffusion tensor imaging study. Addiction Biology, 24(2), 265-274. https://dx.doi.org/10.1111/adb.12599
dc.identifier.doi10.1111/adb.12599
dc.identifier.endpage274
dc.identifier.issn1355-6215
dc.identifier.issn1369-1600
dc.identifier.issue2
dc.identifier.scopusqualityQ1
dc.identifier.startpage265
dc.identifier.urihttps://dx.doi.org/10.1111/adb.12599
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1719
dc.identifier.volume24
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAddiction Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlcohol Use Disorder
dc.subjectEndophenotype
dc.subjectRich Club
dc.subjectStructural Connectivity
dc.subjectWhite Matter
dc.titleRich club and reward network connectivity as endophenotypes for alcohol dependence: A diffusion tensor imaging study
dc.typeArticle

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