Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study

Şahin, Meyha; Mert, Ali; Emecen, Ahmet Naci; Strunjas, Natalija Planinc; Fasanekova, Lenka; Batırel, Ayşe; Erdem, Hakan

Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study

dc.contributor.author	Şahin, Meyha
dc.contributor.author	Mert, Ali
dc.contributor.author	Emecen, Ahmet Naci
dc.contributor.author	Strunjas, Natalija Planinc
dc.contributor.author	Fasanekova, Lenka
dc.contributor.author	Batırel, Ayşe
dc.contributor.author	Erdem, Hakan
dc.date.accessioned	2025-03-12T12:38:03Z
dc.date.available	2025-03-12T12:38:03Z
dc.date.issued	2024
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstract	Objectives: This study of 331 primary brain abscess (PBA) patients aimed to understand infecting agents, predisposing factors, and outcomes, with a focus on factors affecting mortality. Methods: Data were collected from 39 centers across 16 countries between January 2010 and December 2022, and clinical, radiological, and microbiological findings, along with their impact on mortality, were analyzed. Results: The patients had a mean ± SD age of 46.8 ± 16.3 years, with a male predominance of 71.6%. Common symptoms included headache (77.9%), fever (54.4%), and focal neurological deficits (53.5%). Gram-positive cocci were the predominant pathogens, with Viridans group streptococci identified as the most frequently isolated organisms. All patients received antimicrobial therapy and 71.6% underwent interventional therapies. The 42-day and 180-day survival rates were 91.9% and 86.1%, respectively. Significant predictors of 42-day mortality included intravenous drug addiction (HR: 6.02, 95% CI: 1.38-26.26), malignancy (HR: 3.61, 95% CI: 1.23-10.58), confusion (HR: 2.65, 95% CI: 1.19-5.88), and unidentified bacteria (HR: 4.68, 95% CI: 1.76-12.43). Significant predictors of 180-day mortality included malignancy (HR: 2.70, 95% CI: 1.07-6.81), confusion (HR: 2.14, 95% CI: 1.11-4.15), temporal lobe involvement (HR: 2.10, 95% CI: 1.08-4.08), and unidentified bacteria (HR: 3.02, 95% CI: 1.49-6.15). Conclusion: The risk of death in PBA extends beyond the infection phase, with different factors influencing the 42-day and 180-day mortality rates. Intravenous drug addiction was associated with early mortality, while temporal lobe involvement was associated with late mortality.
dc.identifier.citation	Şahin, M., Mert, A., Emecen, A. N., Strunjas, N. P., Fasanekova, L., Batırel, A. ... Erdem, H. (2024). Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study. International Journal of Infectious Diseases, 147. http://dx.doi.org/10.1016/j.ijid.2024.107228
dc.identifier.doi	10.1016/j.ijid.2024.107228
dc.identifier.issn	1201-9712
dc.identifier.issn	1878-3511
dc.identifier.pmid	39216784
dc.identifier.scopus	2-s2.0-85203648875
dc.identifier.scopusquality	Q1
dc.identifier.uri	http://dx.doi.org/10.1016/j.ijid.2024.107228
dc.identifier.uri	https://hdl.handle.net/20.500.12511/12908
dc.identifier.volume	147
dc.identifier.wos	WOS:001318567900001
dc.identifier.wosquality	Q1
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.institutionauthor	Şahin, Meyha
dc.institutionauthor	Mert, Ali
dc.language.iso	en
dc.relation.ispartof	International Journal of Infectious Diseases
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Intravenous Drug Addiction
dc.subject	Microbiological Findings
dc.subject	Mortality
dc.subject	Primary Brain Abscesses
dc.subject	Temporal Lobe Involvement
dc.title	Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study
dc.type	Article