A novel approach to contrast-induced nephrotoxicity: The melatonergic agent agomelatine

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dc.contributor.authorKaraman, Adem
dc.contributor.authorDiyarbakır, Büşra
dc.contributor.authorDurur Subaşı, Irmak
dc.contributor.authorKöse, Duygu
dc.contributor.authorÖzbek Bilgin, Aslı
dc.contributor.authorTopçu, Atilla
dc.contributor.authorGündoğdu, Cemal
dc.contributor.authorDurur Karakaya, Afak
dc.contributor.authorBayraktutan, Zafer
dc.contributor.authorAlper, Fatih
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:57Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:57Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.descriptionWOS: 000376488500007
dc.descriptionPubMed ID: 26886874
dc.description.abstractObjective: To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). The drug's action on the antioxidant system and proinflammatory cytokines, superoxide dismutase (SOD) activity, levels of glutathione (GSH) and malondialdehyde (MDA) and the gene expression of interleukin-6 (IL-6), tumour necrosis factor (TNF)-alpha and nuclear factor kappa B (NF-kappa B) was measured. Tubular necrosis and hyaline and haemorrhagic casts were also histopathologically evaluated. Methods: The institutional ethics and local animal care committees approved the study. Eight groups of six rats were put on the following drug regimens: Group 1: healthy controls, Group 2: GLY (glycerol), Group 3: CM (contrast media-iohexol 10 ml kg(-1)), Group 4: GLY+CM, Group 5: CM+AGO20 (agomelatine 20 mg kg(-1)), Group 6: GLY+CM1AGO20, Group 7: CM1AGO40 (agomelatine 40 mg kg(-1)) and Group 8: GLY+CM+AGO40. The groups were evaluated by one-way analysis of variance and Duncan's multiple comparison test. Results: Agomelatine administration significantly improved the serum levels of blood urea nitrogen (BUN) and creatinine, SOD activity, GSH and MDA. The use of agomelatine had substantial downregulatory consequences on TNF-alpha, NF-kappa B and IL-6 messenger RNA levels. Mild-to-severe hyaline and haemorrhagic casts and tubular necrosis were observed in all groups, except in the healthy group. The histopathological scores were better in the agomelatine treatment groups. Conclusion: Agomelatine has nephroprotective effects against CIN in rats. This effect can be attributed to its properties of reducing oxidative stress and inhibiting the secretion of proinflammatory cytokines (NF-kappa B, TNF-alpha and IL-6). Advances in knowledge: CIN is one of the most important adverse effects of radiological procedures. Renal failure, diabetes, malignancy, old age and nonsteroidal anti-inflammatory drug use pose the risk of CIN in patients. Several clinical studies have investigated ways to avoid CIN. Theophylline/aminophylline, statins, ascorbic acid and iloprost have been suggested for this purpose. Agomelatine is one of the melatonin ligands and is used for affective disorders and has antioxidant features. In this study, we hypothesized that agomelatine could have nephroprotective, antioxidant and anti-inflammatory effects against CIN in rats.
dc.identifier.citationKaraman, A., Diyarbakır, B., Durur Subaşı, I., Köse, D., Özbek Bilgin, A., Topçu, A. ... Alper, F. (2016). A novel approach to contrast-induced nephrotoxicity: The melatonergic agent agomelatine. British Journal Of Radiology, 86(1061). https://dx.doi.org/10.1259/bjr.20150716
dc.identifier.doi10.1259/bjr.20150716
dc.identifier.issn0007-1285
dc.identifier.issn1748-880X
dc.identifier.issue1061
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1259/bjr.20150716
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2113
dc.identifier.volume89
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBritish Inst Radiology
dc.relation.ispartofBritish Journal Of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNovel Approach to Contrast
dc.subjectNephrotoxicity
dc.subjectMelatonergic Agent Agomelatine
dc.titleA novel approach to contrast-induced nephrotoxicity: The melatonergic agent agomelatine
dc.typeArticle

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