Association of tumor strain ratio with prognostic factors in invasive breast cancer

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dc.authorid0000-0002-7034-7806
dc.contributor.authorKaran, Belgin
dc.contributor.authorPurbager, Ayşin
dc.date.accessioned2023-09-20T06:35:34Z
dc.date.available2023-09-20T06:35:34Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractWe evaluate the correlations between tumor strain ratio value and prognostic factors for breast cancers. Fifty-seven women with invasive breast cancer underwent ultrasound elastography prior to surgery. Elastography strain ratio (SR), defined as the fat-to-lesion ratio, was recorded for each lesion using the software in the ultrasound equipment. We evaluated the associations between tumor SR and pathological prognostic factors such as tumor subtype, tumor size, axillary lymph node metastasis, histological grade, vascular invasion, and hormonal receptor status. We found a significant correlation between tumor SR and progesterone receptor (PR) status (p = 0.02). Tumors with axillary lymph node metastasis had a higher SR value than those without lymph node metastasis; however, this difference was not significant. Strain elastography revealed that grade 3 tumors had softer tissues than grade 1 and 2 tumors, although this was not statistically significant. The tumor SR value was not significantly correlated with tumor subtypes, tumor size, vascular invasion, and estrogen receptor or cell surface human epidermal growth factor 2 status (p > 0.05). The present study demonstrated no significant correlation between SR values and prognostic factors, except for PR status. However, tumors with LN metastasis tended to exhibit greater stiffness, and higher grade tumors exhibited lower stiffness owing to necrosis. Further studies with large study population on tumor-associated stiffness are required.
dc.description.sponsorshipBaskent Universityen_US
dc.identifier.citationKaran, B. ve Purbager, A. (2022). Association of tumor strain ratio with prognostic factors in invasive breast cancer. Indian Journal of Surgery, 84(6), 1239-1244. https://doi.org/10.1007/s12262-021-03263-6
dc.identifier.doi10.1007/s12262-021-03263-6
dc.identifier.endpage1244
dc.identifier.issn0972-2068
dc.identifier.issn0973-9793
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85123621338
dc.identifier.scopusqualityQ4
dc.identifier.startpage1239
dc.identifier.urihttps://doi.org/10.1007/s12262-021-03263-6
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11462
dc.identifier.volume84
dc.identifier.wos000749099500006en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKaran, Belgin
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofIndian Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBreast Cancer
dc.subjectElastography
dc.subjectPrognostic Factor
dc.subjectStrain Ratio
dc.titleAssociation of tumor strain ratio with prognostic factors in invasive breast cancer
dc.typeArticle

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