Delivery of curcumin within emulsome nanoparticles enhances the anti-cancer activity in androgen-dependent prostate cancer cell

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dc.authorid0000-0001-9434-3861
dc.contributor.authorBolat, Zeynep Büşra
dc.contributor.authorİşlek, Zeynep
dc.contributor.authorŞahin, Fikrettin
dc.contributor.authorÜçışık, Mehmet Hikmet
dc.date.accessioned2023-05-31T08:46:23Z
dc.date.available2023-05-31T08:46:23Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstractBackground: Curcumin, a dietary polyphenol isolated from turmeric, is a potent phytochemical possessing intrinsic anticancer activities against various cancer types including prostate cancer. However, low water solubility and bioavailability of the compound are major challenges against its medical use. The objective of this study is to evaluate the therapeutic potential of curcumin-loaded emulsome nanoparticular system, i.e. CurcuEmulsomes, for the treatment of androgen dependent LNCaP prostate cancer cell line. Methods and results: The antiproliferative effect of both free curcumin and CurcuEmulsome were investigated comparatively on LNCaP and PNT1A cells. Cell viability data indicates that the inhibition in proliferation of LNCaP cells becomes more effective when curcumin is provided with its emulsome formulation rather than its free form. Corresponding to a therapeutic index of 2.25, Half maximal inhibitory (IC50) and cytotoxic (CC50) concentrations of CurcuEmulsomes for LNCaP and PNT1A cells were estimated as 17.1 µM and 38.6 µM, respectively. The fluorescence signal of autofluorescence curcumin was preserved within the CurcuEmulsomes at 72 h after the treatment. Thus, CurcuEmulsomes prolonged biological activity of curcumin. Induced apoptotic cell death and stimulated cell cycle arrest at G2/M phase were attributed to antiproliferative activity of CurcuEmulsomes. Treatment of LNCaP cells with CurcuEmulsomes increased expression of caspase-3 significantly by 11.76-fold, whereas decreased cyclin D1, Bcl-2 and AR expression levels significantly by of 0.18, 0.06 and 0.46-fold, respectively. Conclusions: Presented safety and anticancer activity of CurcuEmulsomes on LNCaP cell line highlights the potential of CurcuEmulsomes to benefit intrinsic anticancer activities of curcumin in androgen dependent prostate cancer therapy.
dc.description.sponsorshipDepartment of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkeyen_US
dc.identifier.citationBolat, Z. B., İşlek, Z., Şahin, F. ve Üçışık, M. H. (2023). Delivery of curcumin within emulsome nanoparticles enhances the anti-cancer activity in androgen-dependent prostate cancer cell. Molecular Biology Reports, 50(3), 2531-2543. https://doi.org/10.1007/s11033-022-08208-0
dc.identifier.doi10.1007/s11033-022-08208-0
dc.identifier.endpage2543
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue3
dc.identifier.pmid36607480
dc.identifier.scopus2-s2.0-85145867298
dc.identifier.scopusqualityQ2
dc.identifier.startpage2531
dc.identifier.urihttps://doi.org/10.1007/s11033-022-08208-0
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11000
dc.identifier.volume50
dc.identifier.wos000912377500003en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜçışık, Mehmet Hikmet
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/115C022
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAndrogen Dependent Prostate Cancer
dc.subjectAnti-Cancer
dc.subjectCurcumin
dc.subjectEmulsome
dc.subjectPhytochemical
dc.titleDelivery of curcumin within emulsome nanoparticles enhances the anti-cancer activity in androgen-dependent prostate cancer cell
dc.typeArticle

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