Preoperative versus postoperative chemoradiotherapy in stage T3, N0 rectal cancer

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dc.contributor.authorTural, Deniz
dc.contributor.authorSelçukbiricik, Fatih
dc.contributor.authorYıldız, Özcan
dc.contributor.authorElçin, Olgun
dc.contributor.authorErdamar, Sibel
dc.contributor.authorGüney, Sabri
dc.contributor.authorDemireli, Fuat
dc.contributor.authorBüyükünal, Evin
dc.contributor.authorSerdengeçti, Süheyla
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:36Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:36Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000343887400016
dc.descriptionPubMed ID: 24218281
dc.description.abstractThe study populations of previous preoperative chemoradiotherapy (pre-CRT) studies have consisted of mixed clinical stages, such as cT3-cT4 and/or cN positive. For this reason, it has not been possible to demonstrate whether pre-CRT is of benefit for individual subgroups. The medical records of 137 rectal cancer patients with clinical stage T3, N0 disease who received either pre-CRT or postoperative chemoradiotherapy (post-CRT) between 2002 and 2011 were retrospectively analyzed. The regimen of pre-CRT consisted of slow fluorouracil (5FU) infusion and that of post-CRT consisted of bolus 5FU and leucovorin concurrent with radiation. Following pre-CRT, significant downstaging was achieved. However, administration of pre-CRT did not influence the type of surgical resection in tumours a parts per thousand currency sign5 cm distant from the anal verge (p = 0.14). Pathological complete response was achieved in 16 % of the patients in the pre-CRT group. The local recurrence rate (LRR) at 5 years was 5.7 % in the pre-CRT and 11.1 % in the post-CRT groups (p = 0.04). The distant recurrence rate (DRR) at 5 years was 76 % and 77 % in the pre-CRT and post-CRT groups, respectively (p = 0.1). Overall survival was similar in two groups (74.8 % vs. 75.3 %, p = 0.3). The treatment of stage T3, N0 rectal cancer patients with pre-CRT followed by surgery decreased LRR, but did not improve DRR or OS as compared with surgery followed by post-CRT in our patient cohort.
dc.identifier.citationTural, D., Selçukbiricik, F., Yıldız, Ö., Elçin, O., Erdamar, S., Güney, S. ... Serdengeçti, S. (2014). Preoperative versus postoperative chemoradiotherapy in stage T3, N0 rectal cancer. International Journal of Clinical Oncology, 19(5), 889-896.
dc.identifier.doi10.1007/s10147-013-0636-4
dc.identifier.endpage896
dc.identifier.issn1341-9625
dc.identifier.issn1437-7772
dc.identifier.issue5
dc.identifier.scopusqualityQ1
dc.identifier.startpage889
dc.identifier.urihttps://dx.doi.org/10.1007/s10147-013-0636-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2759
dc.identifier.volume19
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Journal of Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPreoperative Chemoradiotherapy
dc.subjectPostoperative Chemoradiotherapy
dc.subjectStage T3 N0 Rectal Adenocarcinoma
dc.subjectOutcome
dc.titlePreoperative versus postoperative chemoradiotherapy in stage T3, N0 rectal cancer
dc.typeArticle

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