Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy

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dc.contributor.authorBilici, Ahmet
dc.contributor.authorAydın, Dinçer
dc.contributor.authorYavuzer, Dilek
dc.contributor.authorOdabaş, Hatice
dc.contributor.authorErcelep, Özlem
dc.contributor.authorYüksel, Sinemis
dc.contributor.authorMert, Aslıhan Güven
dc.contributor.authorÖzçelik, Melike
dc.contributor.authorAliustaoğlu, Mehmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:42Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionGastrointestinal Cancers Symposium -- January 15-17, 2015 -- San Francisco, California
dc.descriptionWOS: 000356883800059
dc.description.abstractBackground: Tumor invasion and metastasis are complex processes, involving regulation at the molecular level of adhesive molecules, proteolitic enzymes, and cell growth and angiogenesis factors. A Disintegrin and Metalloproteinase (ADAM)17 has been indicated to be indispensable regulator of celular event from proliferation to migration.Although prognostic importance of ADAM17 expression has been investigated in several tumors, its clinical utility as a useful prognostic molecular marker remains unclearin gastric cancer.In the present study, we evaluated the expression of ADAM17 and its prognostic significance in gastric cancer patients after surgery. Methods: Prognostic significance of ADAM17 expression was analyzed by immunohistochemically in 158 patients with gastric cancer and the relationship between its expression and clinicopathological factors was also evaluated. Results: High expression of ADAM17 was detected in 81 patients(51%),while low expression was found in 77 cases (49%). There was significant correlation between gender, histology, lymph node metastasis, vascular invasion, the presence of recurrence and high ADAM17 expression. Recurrence in patients with high ADAM17 expression was significantly higher than that for patients with low ADAM17 expression(p=0.032). The median disease-free survival (DFS) time for patients with high ADAM17 expressed tumors were worse than those of patients with low ADAM17 expressed tumor (16.6 vs. 44.2 months, p=0.004).In addition, patients with low ADAM17 expression had a higher median overall survival (OS)interval than those of high ADAM17 expressed patients (49.6 vs. 26.9 months, p=0.019). Multivariate analysis indicated that the rate of ADAM17 expression was an independent prognostic factor for DFS, in addition to known important clinicopathological prognostic indicator for DFS. But its' prognostic importance could not be proved by multivariate analysis for OS. Conclusions: The potential value of ADAM17 expression as a useful molecular marker in gastric cancer progression should be evaluated comprehensively,it may predict recurrence and poor prognosis in patients with gastric cancer after curative resection.
dc.identifier.citationBilici, A., Aydın, D., Yavuzer, D., Odabaş, H., Ercelep, Ö., Yuksel, S. ... Aliustaoğlu, M. (2015). Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy. Gastrointestinal Cancers Symposium, San Francisco, California, January 15-17, 2015. https://dx.doi.org/10.1200/jco.2015.33.3_suppl.60
dc.identifier.doi10.1200/jco.2015.33.3_suppl.60
dc.identifier.issn0732-183X
dc.identifier.issn1527-7755
dc.identifier.issue3
dc.identifier.urihttps://dx.doi.org/10.1200/jco.2015.33.3_suppl.60
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3032
dc.identifier.volume33
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherAmerican Society of Clinical Oncology
dc.relation.ispartofGastrointestinal Cancers Symposiumen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPrognostic
dc.subjectSignificance
dc.subjectGastric Cancer
dc.titlePrognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy
dc.typeConference Object

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