Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury

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dc.authorid0000-0002-7059-1884
dc.authorid0000-0001-7702-2441
dc.authorid0000-0002-6895-8560
dc.authorid0000-0002-1079-8832
dc.authorid0000-0001-6494-8923
dc.contributor.authorKeskin, İlknur
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorAytürk, Nilüfer
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:54Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:54Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.descriptionWOS: 000403378800018
dc.descriptionPubMed ID: 28616032
dc.description.abstractRecent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intra-peritoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.
dc.identifier.citationKeskin, İ., Günal, M. Y., Aytürk, N., Kılıç, Ü., Ozansoy, M. ve Kılıç, E. (2017). Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury. Neural Regeneration Research, 12(5), 761-764. https://dx.doi.org/10.4103/1673-5374.206646
dc.identifier.doi10.4103/1673-5374.206646
dc.identifier.endpage764
dc.identifier.issn1673-5374
dc.identifier.issn1876-7958
dc.identifier.issue5
dc.identifier.scopusqualityQ3
dc.identifier.startpage761
dc.identifier.urihttps://dx.doi.org/10.4103/1673-5374.206646
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3487
dc.identifier.volume12
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedknow Publications & Media Pvt Ltd.
dc.relation.ispartofNeural Regeneration Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/*
dc.subjectNerve Regeneration
dc.subjectNeuroprotection
dc.subjectTraumatic Brain Injury
dc.subjectCold-Induced Brain Injury
dc.subjectEnoxaparin
dc.subjectAnti-Oxidative
dc.subjectApoptosis
dc.subjectNeural Regeneration
dc.titleDose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
dc.typeArticle

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