Clinical and histopathological characteristics of primary focal segmental glomerulosclerosis in Turkish adults

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dc.authorid0000-0003-1185-9737
dc.contributor.authorKurultak, İlhan
dc.contributor.authorGüngör, Özkan
dc.contributor.authorÖztürk, Savaş
dc.contributor.authorDirim, Ahmet Burak
dc.contributor.authorEren, Necmi
dc.contributor.authorYenigün, Ezgi
dc.contributor.authorDal, Elbis Ahbab
dc.contributor.authorDinçer, Mevlüt Tamer
dc.contributor.authorBora, Feyza
dc.contributor.authorAkgür, Suat
dc.contributor.authorSumnu, Abdullah
dc.contributor.authorDursun, Belda
dc.contributor.authorSipahi, Savaş
dc.contributor.authorÇetinkaya, Hakkı
dc.contributor.authorŞahin, İdris
dc.contributor.authorŞahin, Garip
dc.contributor.authorYılmaz, Mürvet
dc.contributor.authorVatansever, Bülent
dc.contributor.authorAydın, Emre
dc.contributor.authorUlu, Memnune Sena
dc.contributor.authorGündoğdu, Ali
dc.contributor.authorÜstündağ, Sedat
dc.contributor.authorSayarlıoğlu, Hayriye
dc.contributor.authorKumru, Gizem
dc.contributor.authorElçioğlu, Ömer C.
dc.contributor.authorAydın, Zeki
dc.contributor.authorSelçuk, Nedim Yılmaz
dc.contributor.authorÖnal Güçlü, Ceren
dc.contributor.authorOruç, Meriç
dc.contributor.authorKüçük, Mehmet
dc.contributor.authorAktaş, Nimet
dc.contributor.authorDerici, Ülver
dc.contributor.authorSüleymanlar, Gültekin
dc.date.accessioned2024-04-04T06:42:10Z
dc.date.available2024-04-04T06:42:10Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractThe data regarding primary FSGS (pFSGS) from different parts of the world differ. While the prevalence of pFSGS has been increasing in Western countries like the USA, it follows an inconsistent trend in Europe and Asia and a decreasing trend in Far Eastern countries such as China in the last two decades. There are undetermined factors to explain those national and geographic discrepancies. Herein, we aimed to reveal the current prevalence with clinical and histopathological characteristics of pFSGS in Turkish adults. This study includes the biopsy-proven pFSGS patients data recorded between 2009 and 2019, obtained from the national multicenter primary glomerulonephritis registry system of the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database. 850 of the 3875 primer glomerulonephritis patients(21.9%) have pFSGS. The mean age is 40.5 ± 14.2 and 435 (51.2%) of patients are male. Nephrotic syndrome is the most common biopsy indication (59.2%). 32.6% of patients have hematuria, 15.2% have leukocyturia and 7.8% have both. Serum creatinine, albumin, and proteinuria are 1.0 mg/dL (IQR = 0.7–1.4) mg/dl, 3.4 ± 0.9 g/dl, 3400 mg/day(IQR, 1774–5740), respectively. Females have lower mean arterial pressure (? 2.2 mmHg), higher eGFR (+ 10.0 mL/min/1.73 m2), and BMI (+ 1.6 kg/m2) than males. Thickened basal membrane(76.6%) and mesangial proliferation (53.5%) on light microscopy are the major findings after segmental sclerosis. IgM (32.7%) and C3 (32.9%) depositions are the most common findings on immunofluorescence microscopy. IgM positivity is related to lower eGFR, serum albumin, and higher proteinuria. The prevalence of pFSGS is stable although slightly increasing in Turkish adults. The characteristics of the patients are similar to those seen in Western countries.
dc.identifier.citationKurultak, İ., Güngör, Ö., Öztürk, S., Dirim, A. B., Eren, N., Yenigün, E. ... Süleymanlar, G. (2024). Clinical and histopathological characteristics of primary focal segmental glomerulosclerosis in Turkish adults. Scientific Reports, (14)1. http://dx.doi.org/10.1038/s41598-024-57305-6
dc.identifier.doi10.1038/s41598-024-57305-6
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid38514826
dc.identifier.scopus2-s2.0-85188245185
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1038/s41598-024-57305-6
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12415
dc.identifier.volume14
dc.identifier.wosWOS:001267554500018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWos
dc.institutionauthorSumnu, Abdullah
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectFSGS
dc.subjectHistopathological features
dc.subjectNephrotic syndrome
dc.subjectPrimary focal segmental glomerulosclerosis
dc.subjectTurkish adults
dc.titleClinical and histopathological characteristics of primary focal segmental glomerulosclerosis in Turkish adults
dc.typeArticle

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