Impact of a novel valerian extract on sleep quality, relaxation, and gaba/serotonin receptor activity in a murine model

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dc.authorid0000-0003-3886-2151
dc.contributor.authorŞahin, Kazım
dc.contributor.authorGençoğlu, Hasan
dc.contributor.authorKorkusuz, Ahmet Kayhan
dc.contributor.authorOrhan, Cemal
dc.contributor.authorAldatmaz, İsmail Ertuğ
dc.contributor.authorErten, Füsun
dc.contributor.authorEr, Beşir
dc.contributor.authorMorde, Abhijeet
dc.contributor.authorPadigaru, Muralidhara
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2024-07-05T11:02:06Z
dc.date.available2024-07-05T11:02:06Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractInsomnia is a major global health issue, highlighting the need for treatments that are both effective and safe. Valerian extract, a traditional remedy for sleep problems, offers potential therapeutic options. This research examined the potential sleep-enhancing effects of VA (Valerian Pdr%2) in mice. The study evaluated sleep quality by comparing the impact of the VA extract against melatonin on brain activity, using electrocorticography (ECoG) to assess changes in brain waves. For this purpose, the study utilized two experimental models on BALB/c mice to explore the effects of caffeine-induced insomnia and pentobarbital-induced sleep. In the first model, 25 mice were assigned to five groups to test the effects of caffeine (caffeine, 7.5 mg/kg i.p) alone, caffeine with melatonin (2 mg/kg), or caffeine with different doses of valerian extract (100 or 300 mg/kg) given orally on brain activity, assessed via electrocorticography (ECoG) and further analyses on the receptor proteins and neurotransmitters. In the second model, a different set of 25 mice were divided into five groups to examine the impact of pentobarbital (42 mg/kg) alone, with melatonin, or with the valerian extract on sleep induction, observing the effects 45 min after administration. The study found that ECoG frequencies were lower in groups treated with melatonin and two doses of valerian extract (100 and 300 mg/kg), with 300 mg/kg showing the most significant effect in reducing frequencies compared to the caffeine control group, indicating enhanced sleep quality (p < 0.05). This was supported by increased levels of serotonin, melatonin, and dopamine and higher levels of certain brain receptors in the melatonin and valerian extract groups (p < 0.05). Modulatory efficacy for the apoptotic markers in the brain was also noted (p < 0.05). Additionally, melatonin and both doses of VA increased sleep duration and reduced sleep onset time compared to the pentobarbital control, which was particularly notable with high doses. In conclusion, the findings suggest that high doses (300 mg/kg) of valerian extract enhance both the quantity and quality of sleep through the GABAergic pathway and effectively increase sleep duration while reducing the time to fall asleep in a pentobarbital-induced sleep model in mice.
dc.description.sponsorshipOmniActive Health Technologies--Turkish Academy of Sciencesen_US
dc.identifier.citationŞahin, K., Gençoğlu, H., Korkusuz, A. K., Orhan, C., Aldatmaz, İ. E., Erten, F. ... Kılıç, E. (2024). Impact of a novel valerian extract on sleep quality, relaxation, and gaba/serotonin receptor activity in a murine model. Antioxidants, 13(6). http://dx.doi.org/10.3390/antiox13060657
dc.identifier.doi10.3390/antiox13060657
dc.identifier.issn2076-3921
dc.identifier.issue6
dc.identifier.pmid38929096
dc.identifier.scopus2-s2.0-85197868072
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.3390/antiox13060657
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12706
dc.identifier.volume13
dc.identifier.wos001254922800001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKorkusuz, Ahmet Kayhan
dc.institutionauthorAldatmaz, İsmail Ertuğ
dc.language.isoen
dc.relation.ispartofAntioxidantsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCaffeine
dc.subjectMelatonin
dc.subjectValerian
dc.subjectSleep Disturbance
dc.subjectNeurotransmitters
dc.subjectApoptosis
dc.titleImpact of a novel valerian extract on sleep quality, relaxation, and gaba/serotonin receptor activity in a murine model
dc.typeArticle

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