Embryonic microenvironment suppresses YY1 and YY1-related genes in prostate cancer stem cells

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dc.authorid0000-0003-0128-6947
dc.contributor.authorTaşkıran, Ayşegül
dc.contributor.authorÖktem, Gülperi
dc.contributor.authorDemir, Aleyna
dc.contributor.authorOltulu, Fatih
dc.contributor.authorÖzçınar, Emine
dc.contributor.authorDüzağaç, Fahriye
dc.contributor.authorGüven, Ümmü
dc.contributor.authorKarakoç, Emre
dc.contributor.authorÇakır, Aslı
dc.contributor.authorAyla, Şule
dc.contributor.authorGüven, Selçuk
dc.contributor.authorAçıkgöz, Eda
dc.date.accessioned2024-08-27T05:31:40Z
dc.date.available2024-08-27T05:31:40Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractYin yang 1 (YY1), a transcription factor, plays crucial roles in cell fate specification, differentiation, and pluripotency during embryonic development. It is also involved in tumorigenesis, drug resistance, metastasis, and relapse caused by cancer stem cells (CSCs), particularly in prostate cancer (PCa). Targeting YY1 could potentially eliminate prostate CSCs (PCSCs) and provide novel therapeutic approaches. PCa tissues often exhibit elevated YY1 expression levels, especially in high-grade cases. Notably, high-grade PCa tissues from 58 PCa patients and CD133high/CD44high PCSCs isolated from DU145 PCa cell line by FACS both showed significantly increased YY1 expression as observed through immunofluorescence staining, respectively. To investigate the embryonic microenvironment impact on YY1 expression in CSC populations, firstly PCSCs were microinjected into the inner cell mass of blastocysts and then PCSCs were co-cultured with blastocysts. Next Generation Sequencing was used to analyze alterations in YY1 and related gene expressions. Interestingly, exposure to the embryonic microenvironment significantly reduced the expressions of YY1, YY2, and other relevant genes in PCSCs. These findings emphasize the tumor-suppressing effects of the embryonic environment by downregulating YY1 and YY1-related genes in PCSCs, thus providing promising strategies for PCa therapy. Through elucidating the mechanisms involved in embryonic reprogramming and its effects on YY1 expression, this research offers opportunities for further investigation into focused therapies directed against PCSCs, therefore enhancing the outcomes of PCa therapy. As a result, PCa tumors may benefit from YY1 and associated genes as a novel therapeutic target.
dc.identifier.citationTaşkıran, A., Öktem, G., Demir, A., Oltulu, F., Özçınar, E., Düzağaç, F. ... Açıkgöz, E. (2024). Embryonic microenvironment suppresses YY1 and YY1-related genes in prostate cancer stem cells. Pathology Research and Practice, 260. http://dx.doi.org/10.1016/j.prp.2024.155467
dc.identifier.doi10.1016/j.prp.2024.155467
dc.identifier.issn0344-0338
dc.identifier.issn1618-0631
dc.identifier.pmid39047662
dc.identifier.scopus2-s2.0-85199310983
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1016/j.prp.2024.155467
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12772
dc.identifier.volume260
dc.identifier.wos001280630200001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇakır, Aslı
dc.language.isoen
dc.relation.ispartofPathology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCancer Stem Cell
dc.subjectEmbryonic Microenvironment
dc.subjectProstate Cancer
dc.subjectReprogramming
dc.subjectYin Yang 1
dc.titleEmbryonic microenvironment suppresses YY1 and YY1-related genes in prostate cancer stem cells
dc.typeArticle

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