Utilization of focal therapy for patients discontinuing active surveillance of prostate cancer: Recommendations of an international delphi consensus

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dc.authorid0000-0002-6308-1763
dc.contributor.authorTan, Wei Phin
dc.contributor.authorRastinehad, Ardeshir R.
dc.contributor.authorKlotz, Laurence
dc.contributor.authorCarroll, Peter R.
dc.contributor.authorEmberton, Mark
dc.contributor.authorFeller, John F.
dc.contributor.authorGeorge, Arvin K.
dc.contributor.authorGill, Inderbir S.
dc.contributor.authorGupta, Rajan T.
dc.contributor.authorKatz, Aaron E.
dc.contributor.authorLebastchi, Amir H.
dc.contributor.authorMarks, Leonard S.
dc.contributor.authorMarra, Giancarlo
dc.contributor.authorPinto, Peter A.
dc.contributor.authorSong, Daniel Y.
dc.contributor.authorSidana, Abhinav
dc.contributor.authorWard, John F.
dc.contributor.authorSanchez-Salas, Rafael
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorPolascik, Thomas J.
dc.date.accessioned2021-12-06T12:59:11Z
dc.date.available2021-12-06T12:59:11Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractBackground: With the advancement of imaging technology, focal therapy (FT) has been gaining acceptance for the treatment of select patients with localized prostate cancer (CaP). We aim to provide details of a formal physician consensus on the utilization of FT for patients with CaP who are discontinuing active surveillance (AS). Methods: A 3-stage Delphi consensus on CaP and FT was conducted. Consensus was defined as agreement by >= 80% of physicians. An in-person meeting was attended by 17 panelists to formulate the consensus statement. Results: Fifty-six respondents participated in this interdisciplinary consensus study (82% urologist, 16% radiologist, 2% radiation oncology). The participants confirmed that there is a role for FT in men discontinuing AS (48% strongly agree, 39% agree). The benefit of FT over radical therapy for men coming off AS is: less invasive (91%), has a greater likelihood to preserve erectile function (91%), has a greater likelihood to preserve urinary continence (91%), has fewer side effects (86%), and has early recovery post-treatment (80%). Patients will need to undergo mpMRI of the prostate and/or a saturation biopsy to determine if they are potential candidates for FT. Our limitations include respondent's biases and that the participants of this consensus may not represent the larger medical community. Conclusions: FT can be offered to men coming off AS between the age of 60 to 80 with grade group 2 localized cancer. This consensus from a multidisciplinary, multi-institutional, international expert panel provides a contemporary insight utilizing FT for CaP in select patients who are discontinuing AS.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA ; European Urological Scholarship Programme (EUSP)en_US
dc.identifier.citationTan, W. P., Rastinehad, A. R., Klotz, L., Carroll, P. R., Emberton, M., Feller, J. F. ... Polascik, T. J. (2021). Utilization of focal therapy for patients discontinuing active surveillance of prostate cancer: Recommendations of an international delphi consensus. Urologic Oncology: Seminars and Original Investigations, 39(11). https://dx.doi.org/10.1016/j.urolonc.2021.01.027
dc.identifier.doi10.1016/j.urolonc.2021.01.027
dc.identifier.issn1078-1439
dc.identifier.issn1873-2496
dc.identifier.issue11
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1016/j.urolonc.2021.01.027
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8620
dc.identifier.volume39
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofUrologic Oncology: Seminars and Original Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectActive Surveillance
dc.subjectFocal Therapy
dc.subjectLocalized Prostate Cancer
dc.subjectPartial Gland Ablation
dc.titleUtilization of focal therapy for patients discontinuing active surveillance of prostate cancer: Recommendations of an international delphi consensus
dc.typeArticle

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