On-demand modafinil improves ejaculation time and patient-reported outcomes in men with lifelong premature ejaculation

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dc.contributor.authorTüken, Murat
dc.contributor.authorKiremit, Murat Can
dc.contributor.authorŞerefoğlu, Ege Can
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:04:26Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:04:26Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.descriptionWOS: 000383696400037
dc.descriptionPubMed ID: 27151339
dc.description.abstractOBJECTIVE To evaluate the effects of modafinil on the intravaginal ejaculatory latency time (IELT) and patient-reported outcomes in patients with lifelong premature ejaculation (PE). PATIENTS AND METHODS Treatment-naive lifelong PE patients were included in this proof-of-concept study. Self-estimated IELTs of the patients were recorded and the Premature Ejaculation Profile (PEP) questionnaire was administered before the initiation of on-demand modafinil 100 mg treatment. At the end of 1 month of treatment, self-estimated IELTs were recorded again, along with posttreatment PEP outcomes. RESULTS Overall, 55 lifelong PE patients with a mean age of 35.07 +/- 7.80 (range: 22-58) years were enrolled. Modafinil treatment modestly increased the mean IELT at the end of 1 month (24.82 +/- 16.10 seconds vs 49.82 +/- 31.46 seconds, P =.0001). Moreover, at the end of 1 month, patients reported in the PEP questionnaire better control over ejaculation (0.75 +/- 0.67 vs 1.35 +/- 0.91, P =.0001), improved satisfaction with sexual intercourse (0.98 +/- 0.78 vs 1.40 +/- 0.85, P =.0001), lesser personal distress (0.42 +/- 0.69 vs 0.89 +/- 1.01, P =.0001), and reduced interpersonal difficulty (1.69 +/- 1.48 vs 1.95 +/- 1.47, P =.0001). CONCLUSION In an uncontrolled proof-of-concept study of men with treatment-naive lifelong PE where IELT was self-reported without a stopwatch, modest improvements of both IELT and patient-reported outcome measures were observed. Future controlled clinical trials are necessary to confirm these findings.
dc.identifier.citationTüken, M., Kiremit, Murat C. ve Şerefoğlu, Ege C. (2016). On-demand modafinil improves ejaculation time and patient-reported outcomes in men with lifelong premature ejaculation. Urology, 94. 139-142. https://dx.doi.org/10.1016/j.urology.2016.04.036
dc.identifier.doi10.1016/j.urology.2016.04.036
dc.identifier.endpage142
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.scopusqualityQ1
dc.identifier.startpage139
dc.identifier.urihttps://dx.doi.org/10.1016/j.urology.2016.04.036
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4051
dc.identifier.volume94
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOn-Demand Modafinil
dc.subjectImproves Ejaculation
dc.subjectLifelong Premature Ejaculation
dc.titleOn-demand modafinil improves ejaculation time and patient-reported outcomes in men with lifelong premature ejaculation
dc.typeArticle

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