Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells

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dc.authorid0000-0003-0957-6965
dc.contributor.authorSucu, Bilgesu Onur
dc.date.accessioned2022-11-15T13:19:40Z
dc.date.available2022-11-15T13:19:40Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalı
dc.description.abstractImidazo[1,2-a]pyridine cores have increasing importance in the pharmaceutical industry with their wide range pharmacological activities. In this study, two series of imidazopyridine derivatives were synthesized. It was planned to integrate the pyrimidine ring or N-acylhydrazone (NAH) to the carbon atom at the 3 position of the imidazo[1,2-a]pyridine scaffold. Pyrimidine-containing compounds (9-12) were obtained by palladium-catalyzed coupling reaction (Suzuki reaction), and NAH compounds (13-19) were obtained from the aldehyde intermediate synthesized as a result of the Vilsmeier-Haack reaction. All of the derivatives were evaluated in breast cancer cells for their antiproliferative potential. The pyrimidine-containing compounds did not show active results in both breast cancer cell lines, while the NAH derivatives showed significant results. Among the novel derivatives, compound 15 exhibited the most potent activity against the MCF7 and MDA-MB-231 cell lines with IC50 values of 1.6 and 22.4 mu M, respectively. The current study demonstrated that these compounds have anticancer activity and would be useful in developing more effective compounds for treating breast cancer.
dc.identifier.citationSucu, B. O. (2022). Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells. Medicinal Chemistry Research, 31(12), 2231-2242. https://doi.org/10.1007/s00044-022-02984-x
dc.identifier.doi10.1007/s00044-022-02984-x
dc.identifier.endpage2242
dc.identifier.issn1054-2523
dc.identifier.issn1554-8120
dc.identifier.issue12
dc.identifier.scopus2-s2.0-85141097873
dc.identifier.scopusqualityQ2
dc.identifier.startpage2231
dc.identifier.urihttps://doi.org/10.1007/s00044-022-02984-x
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9967
dc.identifier.volume31
dc.identifier.wos000871850700001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSucu, Bilgesu Onur
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMedicinal Chemistry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcylhydrazone
dc.subjectAnticancer Agent
dc.subjectBreast Cancer
dc.subjectImidazo[1,2-a]Pyridine
dc.subjectSuzuki
dc.titleBiological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells
dc.typeArticle

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