Effects of erythropoietin on spontaneous and oxytocin induced myometrial contractions in the nonpregnant rat

Basit Öğe Kaydı
dc.authorid0000-0001-6494-8923
dc.contributor.authorTuğ, Niyazi
dc.contributor.authorAyvacı Tasan, Habibe
dc.contributor.authorSargın, Mehmet Akif
dc.contributor.authorDoğan Taymur, Bilge
dc.contributor.authorAyar, Ahmet
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorYılmaz, Bayram
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:55:57Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:55:57Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000417908300002
dc.descriptionPubMed ID: 29228453
dc.description.abstractOBJECTIVE: Erythropoietin (EPO) is a glycoprotein hormone that regulates erythropoiesis. EPO activity has also been detected in a variety of tissue including the nervous system, and female and male reproductive organs. It has been shown that EPO causes relaxation in vascular smooth muscle. In the present study, we have investigated effects of EPO on spontaneous and oxytocin-induced contractions of non-pregnant rat myometrium. MATERIALS AND METHODS: Myometrial stripes were obtained from adult Wistar rats at the oestrous stage. The samples were placed in an isolated organ chamber under physiological conditions and 1 g passive tension. Epoetin beta (rEPO) was added cumulatively at 0.1, 1 and 10 IU/ml concentrations to the myometrial samples showing regular spontaneous contractions for periods of 30 min. Frequency and amplitude of contractions were electrophysiologically recorded and analyzed by using a BIOPAC data acquisition system. RESULTS: rEPO inhibited both area under curve and frequency of spontaneous contractions (ANOVA, n1, 2 = 9, f1 = 20.938, f2 = 20.492, p1,2 = 0.000). The inhibitory effect was insignificant at 0.1 mIU/ml rEPO level (Tukey HSD, p1 = 0.051, p2 = 0.581). In the oxytocin treated myometrial samples, a single dose of 1 IU/ml rEPO was studied. The area under curve and frequency values of these samples were inhibited by rEPO (Student's t-test, n = 9, t1 = 4.776, p1 = 0.000; t2 = 2.835, p2 = 0.012, respectively). CONCLUSIONS: rEPO inhibited spontaneous and oxytocin-induced rat myometrial contractions at 1 and 10 IU/ml concentrations. It appeared that the effect was dose-dependent.
dc.description.sponsorshipYeditepe University Research Foundationen_US
dc.description.sponsorshipThis study was supported by Yeditepe University Research Foundation.en_US
dc.identifier.citationTuğ, N., Ayvacı Tasan, H., Sargın, M. A., Doğan, Taymur, B., Ayar, A., Kılıç, E. ... Yılmaz, B. (2017). Effects of erythropoietin on spontaneous and oxytocin induced myometrial contractions in the nonpregnant rat. European Review For Medical and Pharmacological Sciences, 21(22), 5028-2033. https://dx.doi.org/10.26355/eurrev_201711_13814
dc.identifier.endpage5033
dc.identifier.issn1128-3602
dc.identifier.issue22
dc.identifier.scopusqualityQ2
dc.identifier.startpage5028
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2490
dc.identifier.urihttps://dx.doi.org/10.26355/eurrev_201711_13814
dc.identifier.volume21
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectErythropoietin
dc.subjectEPO
dc.subjectEpoetin
dc.subjectMyometrium
dc.subjectContractility
dc.titleEffects of erythropoietin on spontaneous and oxytocin induced myometrial contractions in the nonpregnant rat
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
tug(2017).pdf
Boyut:
571.21 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu