Impact of sarcopenia and vitamin D levels on the severity of lower urinary tract symptoms in older males

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dc.authorid0000-0002-5356-303X
dc.contributor.authorMut Sürmeli, Deniz
dc.contributor.authorKarpuzcu, Hulusi Can
dc.contributor.authorAtmış, Volkan
dc.contributor.authorCoşarderelioğlu, Çağlar
dc.contributor.authorYalçın, Ahmet
dc.contributor.authorVarlı, Murat
dc.contributor.authorAras, Sevgi
dc.date.accessioned2024-06-12T11:54:54Z
dc.date.available2024-06-12T11:54:54Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractOBJECTIVES: To assess the impact of sarcopenia and vitamin D levels on the severity of lower urinary tract symptoms (LUTS). METHODS: A total of 193 male patients, aged 60 years and above, who visited the geriatric outpatient clinic at Ibn-i Sina Hospital in Ankara, Turkey, between December 2019 and March 2021, were enrolled. Sarcopenia was diagnosed according to the criteria set by the European Working Group on Sarcopenia in Older People. The presence and severity of lower urinary tract symptoms were assessed using the International Prostate Symptom Score questionnaire, categorizing symptom severity as mild or moderate-to-severe. RESULTS: The median patient age was 71 years (range: 66-77). Sarcopenia affected 24.9% of the population studied. Mild LUTS was observed in 43.5% and moderate-to-severe LUTS was observed in 56.5% of patients. Sarcopenia prevalence was significantly higher in the individuals with moderate-to-severe LUTS compared to those with mild-LUTS (p=0.021). After adjusting for Charlson comorbidity index and age, only vitamin D levels were significantly associated with increased odds of moderate-to-severe LUTS (odds ratio [OR]=0.95, 95% confidence interval [CI]: [0.92-0.98], p=0.002). Sarcopenia was not significantly associated with the severity of LUTS (OR=2.04, 95% CI: [0.94-4.45], p=0.070). An inverse linear trend was observed between quartiles of 25 (OH) vitamin D and LUTS severity. As 25 (OH)vitamin D levels increased, the proportion of patients with moderate-to-severe LUTS decreased (p=0.023). CONCLUSION: Sarcopenia did not significantly impact LUTS severity, but low vitamin D levels were associated with moderate-to-severe LUTS.
dc.identifier.citationMut Sürmeli, D., Karpuzcu, H. C., Atmış, V., Coşarderelioğlu, Ç., Yalçın, A., Varlı, M. ... Aras, S. (2024). Impact of sarcopenia and vitamin D levels on the severity of lower urinary tract symptoms in older males. Saudi Medical Journal, 45(6), 598-605. http://dx.doi.org/10.15537/smj.2024.45.6.20240166
dc.identifier.doi10.15537/smj.2024.45.6.20240166
dc.identifier.endpage605
dc.identifier.issn1658-3175
dc.identifier.issue6
dc.identifier.pmid38830659
dc.identifier.scopus2-s2.0-85194993953
dc.identifier.scopusqualityQ3
dc.identifier.startpage598
dc.identifier.urihttp://dx.doi.org/10.15537/smj.2024.45.6.20240166
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12633
dc.identifier.volume45
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAras, Sevgi
dc.language.isoen
dc.relation.ispartofSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAged
dc.subjectLower Urinary Tract Symptoms
dc.subjectProstatic Hyperplasia
dc.subjectSarcopenia
dc.subjectVitamin D
dc.titleImpact of sarcopenia and vitamin D levels on the severity of lower urinary tract symptoms in older males
dc.typeArticle

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