Adverse drug reactions affecting treatment adherence in first-line treatment of asthma: An observational study

Bahçeci Erdem, Semiha; Nacaroğlu, Hikmet Tekin; Can, Demet

Adverse drug reactions affecting treatment adherence in first-line treatment of asthma: An observational study

dc.authorid	0000-0003-1333-2648
dc.contributor.author	Bahçeci Erdem, Semiha
dc.contributor.author	Nacaroğlu, Hikmet Tekin
dc.contributor.author	Can, Demet
dc.date.accessioned	2023-03-28T07:48:17Z
dc.date.available	2023-03-28T07:48:17Z
dc.date.issued	2023
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstract	BACKGROUND: Asthma is the most common chronic lung disease among children. International guidelines recommend inhaled corticosteroids (ICS) as the first-line daily controller therapy for children with asthma and leukotriene receptor antagonists (LTRA) as the second alternative therapy. Adherence to treatment is the most significant component to optimize the benefits of therapy in asthma. OBJECTIVE: This study aims to investigate the frequency of drug discontinuation due to adverse drug reactions (ADRs) that affect adherence to treatment in children with asthma or asthma and allergic rhinitis using LTRA or ICS as monotherapy. METHODS: The subjects aged 4-18 years with asthma or asthma and allergic rhinitis and using montelukast or ICS as monotherapy were included in the study. They were evaluated in terms of ADRs affecting adherence to treatment in the first and third months of treatment. RESULTS: A total of 468 cases, 356 of whom received montelukast monotherapy and 112 of whom received ICS treatment, with a mean age of 9.10 ± 3.08 (4-17) years, were included in the study. Males constituted 65.6% of the total cases (n = 307). In the first month of follow-up of the cases, it was observed that 4.8% (n = 17) of the patients in the montelukast group could not continue the treatment due to ADR. It was determined that the drug discontinuation rate in the montelukast group in the first month was significantly higher than in the ICS group (P = 0.016), and the risk of drug discontinuation due to ADR in the montelukast group was 1.333 (95% CI, 1.26-1.40) times higher. CONCLUSIONS: As a result, it was observed that the drug was discontinued due to ADR at a higher rate in children with asthma who received montelukast monotherapy compared to those who received ICS monotherapy.
dc.identifier.citation	Bahçeci Erdem, S., Nacaroğlu, H. T. ve Can, D. (2023). Adverse drug reactions affecting treatment adherence in first-line treatment of asthma: An observational study. Allergologia et Immunopathologia, 51(2), 11-16. https://dx.doi.org/10.15586/aei.v51i2.774
dc.identifier.doi	10.15586/aei.v51i2.774
dc.identifier.endpage	16
dc.identifier.issn	0301-0546
dc.identifier.issn	1578-1267
dc.identifier.issue	2
dc.identifier.pmid	36916083
dc.identifier.scopus	2-s2.0-85150083838
dc.identifier.scopusquality	Q3
dc.identifier.startpage	11
dc.identifier.uri	https://dx.doi.org/10.15586/aei.v51i2.774
dc.identifier.uri	https://hdl.handle.net/20.500.12511/10719
dc.identifier.volume	51
dc.identifier.wos	001011038000002	en_US
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.institutionauthor	Nacaroğlu, Hikmet Tekin
dc.language.iso	en
dc.publisher	NLM (Medline)
dc.relation.ispartof	Allergologia et Immunopathologia	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Adherence
dc.subject	Adverse Drug Reaction
dc.subject	Asthma
dc.subject	Hallucination
dc.subject	Inhaled Corticosteroids
dc.subject	Leukotriene Receptor Antagonists
dc.subject	Montelukast
dc.subject	Steroid Phobia
dc.title	Adverse drug reactions affecting treatment adherence in first-line treatment of asthma: An observational study
dc.type	Article