Can the imbalance between neurotrophic and apoptotic proteins be the "beware the ides of march" for unaffected relatives of schizophrenia patients?

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dc.authorid0000-0001-8521-1613
dc.contributor.authorYeşilkaya, Ümit Haluk
dc.contributor.authorGıca, Şakir
dc.contributor.authorÖzkara Menekşeoğlu, Pelin
dc.contributor.authorGüney Taşdemir, Büşra
dc.contributor.authorÇıraklı, Zeynep
dc.contributor.authorKaramustafalıoğlu, Nesrin
dc.date.accessioned2022-11-16T07:45:24Z
dc.date.available2022-11-16T07:45:24Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Sinirbilim Ana Bilim Dalı
dc.description.abstractSchizophrenia (SZ) is a mental disorder with a strong genetic basis as well as epigenetic aspects. Siblings of patients with SZ can share certain endophenotypes with the patients, suggesting that siblings may be important for distinguishing between trait and state markers. In the current study, we aimed to characterize the balance between pro-BDNF/mature BDNF and its receptors p75NTR/TrkB, which are tPA-BDNF pathways proteins and are thought to play a role in synaptic pruning, as a possible endophenotype of schizophrenia. Forty drug-naive patients with first-episode psychosis (FEP) matched for age, gender, and level of education, 40 unaffected siblings (UAS) of patients with FEP, and 67 healthy controls (HC) were included in the study. Blood samples were collected from all participants to determine BDNF, pro-BDNF, TrkB and p75NTR, PAI1, tPA, ACTH, and cortisol levels. We showed that levels of proteins of the tPA-BDNF pathway as well as the pro-BDNF/m-BDNF and p75NTR/TrkB ratios could successfully differentiate FEP and their siblings from the HCs by using ROC analysis. Plasma levels of m-BDNF were found to be the lowest in the healthy siblings and highest in the HCs with statistically significant differences between all 3 groups. The plasma level of pro-BDNF in the HC group was similar to the FEP patients, the same in the healthy siblings of the FEP patients. Our data support the hypothesis that imbalance between neurotrophic and apoptotic proteins might occur in SZ and this imbalance could be an endophenotype of the disease.
dc.description.sponsorshipUniversity of (University of Health Sciences Turkey) Research Projects Uniten_US
dc.identifier.citationYeşilkaya, Ü. H., Gıca, Ş., Özkara Menekşeoğlu, P., Güney Taşdemir, B., Çıraklı, Z. ve Karamustafalıoğlu, N. (2022). Can the imbalance between neurotrophic and apoptotic proteins be the "beware the ides of march" for unaffected relatives of schizophrenia patients? Molecular Neurobiology, 59(12), 7413-7422. https://doi.org/10.1007/s12035-022-03054-4
dc.identifier.doi10.1007/s12035-022-03054-4
dc.identifier.endpage7422
dc.identifier.issn0893-7648
dc.identifier.issn1559-1182
dc.identifier.issue12
dc.identifier.pmid36190691
dc.identifier.scopus2-s2.0-85139666283
dc.identifier.scopusqualityQ1
dc.identifier.startpage7413
dc.identifier.urihttps://doi.org/10.1007/s12035-022-03054-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9969
dc.identifier.volume59
dc.identifier.wos000865209800001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYeşilkaya, Ümit Haluk
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Neurobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectBDNF
dc.subjectEndophenotype
dc.subjectNeurotrophin
dc.subjectSchizophrenia
dc.subjectSynaptic Pruning
dc.titleCan the imbalance between neurotrophic and apoptotic proteins be the "beware the ides of march" for unaffected relatives of schizophrenia patients?
dc.typeArticle

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