Dipyrone attenuates cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits

Basit Öğe Kaydı
dc.contributor.authorSilav, Gökalp
dc.contributor.authorErgün, Hakan
dc.contributor.authorDolgun, Habibullah
dc.contributor.authorSancak, Tanzer
dc.contributor.authorSargon, Mustafa Fevzi
dc.contributor.authorEgemen, Nihat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:46Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:46Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.descriptionWOS: 000410533100004
dc.descriptionPubMed ID: 25366581
dc.description.abstractBACKGROUND: The purpose of this study was to evaluate the effect of the systemic administration of dipyrone in a triple subarachnoid hemorrhage (SAH) model of cerebral vasospasm in rabbits. METHODS: Experimental subarachnoid hemorrhage was induced in rabbits by injecting autologous arterial blood into the cisterna magna. Digital subtraction angiographies (DSA) were performed before and after the first experimental SAH, and at 30, 45, 60 minutes and 72 hours after the first drug administration to measure the diameter of basilar artery. Intracisternal blood injections were repeated 24 and 48 hours after the first injection. Dipyrone (N.= 20) or 0.9% NaCl (N.= 20) was administered intravenously after initial SAH induction and repeated at 8-hour intervals intramuscularly. After sacrificing by perfusion-fixation, basilar arteries were removed and sectioned for transmission electron microscopic (TEM) examination. RESULTS: The average basilar artery diameter measured by DSA was 724 +/- 19 mu m in the control, and 686 +/- 29 mu m in treatment group before SAH. After SAH, mean basilar artery diameters decreased to 71% and 68% of their basal values, respectively. Dipyrone significantly attenuated the basilar artery diameter at one and 72 hours after the first drug administration, in comparison to the control group. TEM studies showed more edema in the endothelial cells of the basilar arteries of the control group when compared to the treatment group. CONCLUSIONS: Dipyrone showed a beneficial effect in autologous blood-induced basilar artery vasospasm in rabbits. These data support the idea that dipyrone can be a potential candidate drug to be tested in patients suffering from cerebral vasospasm secondary to subarachnoid hemorrhage.
dc.identifier.citationSilav, G., Ergün, H., Dolgun, H., Sancak, T., Sargon, M. F. ve Egemen, N. (2017). Dipyrone attenuates cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits. Journal of Neurosurgical Sciences, 61(4), 380-387. https://dx.doi.org/10.23736/S0390-5616.16.03068-X
dc.identifier.doi10.23736/S0390-5616.16.03068-X
dc.identifier.endpage387
dc.identifier.issn0390-5616
dc.identifier.issn1827-1855
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage380
dc.identifier.urihttps://dx.doi.org/10.23736/S0390-5616.16.03068-X
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3224
dc.identifier.volume61
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofJournal of Neurosurgical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBasilar artery
dc.subjectIntercranial Vasospasm
dc.subjectDipyrone
dc.subjectRabbits
dc.titleDipyrone attenuates cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu