GATA3 expression and its relationship with clinicopathological parameters in invasive breast carcinomas

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dc.authorid0000-0003-0128-6947
dc.contributor.authorÇakır, Aslı
dc.contributor.authorIşık Gönül, İpek
dc.contributor.authorEkinci, Özgür
dc.contributor.authorÇetin, Bülent Eren
dc.contributor.authorBenekli, Mustafa
dc.contributor.authorUluoğlu, Ömer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:23Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:23Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000397371700010
dc.descriptionPubMed ID: 28215639
dc.description.abstractGATA3, as a transcription factor, is associated with estrogen receptor (ER) expression and necessary for luminal cell differentiation in mammary glands. Association of GATA3 expression with clinicopathological parameters, molecular subtypes of tumors, disease free survival (DFS) and overall survival (OS) for breast carcinoma patients were evaluated in this study. We immunohistochemically stained GATA3, CK5/6, EGFR, CK14 and vimentin on tissue microarray blocks of 457 invasive breast carcinomas. Tumors are sub-classified as luminal A, luminal B, HER2 expressing, basal-like and null type according to their hormonal status with cerbB2, CK 5/6 and EGFR expressions. Follow-up data for 254 cases were obtained. 215/457 (47%) tumors were GATA3 positive. GATA3 expression was inversely correlated with mitotic count (p < 0.0001), nuclear grade (p = 0.001), histological grade (p = 0.001), tumor necrosis (p = 0.001), stromal lymphocytic response (p < 0.01), nipple invasion (p = 0.01), metastasis (p = 0.03), vimentin (p = 0.0003), EGFR (p = 0.015) and CK14 (p = 0.001) expressions; and directly associated with ER (p < 0.0001) and progesterone receptor (PR) (p < 0.0001) expressions. Luminal A carcinomas had the highest frequency for GATA-3 (140/245), however basal-like carcinomas had the lowest (1/42) (p < 0.0001). None of the medullary and metaplastic carcinomas expressed GATA3. GATA3 was associated with good DFS and OS (p = 0.001 and p = 0.0009) and was an independent prognostic factor for OS. GATA3 expression, regardless of the subtype, may have a prognostic significance for breast carcinomas through its ability to promote the differentiation of luminal progenitor cells.
dc.identifier.citationÇakır, A., Işık Gönül, İ., Ekinci, Ö., Çetin, B., E., Benekli, M. ve Uluoğlu, Ö. (2017). GATA3 expression and its relationship with clinicopathological parameters in invasive breast carcinomas. Pathology Research and Practice, 213(3), 227-234. https://dx.doi.org/10.1016/j.prp.2016.12.010
dc.identifier.doi10.1016/j.prp.2016.12.010
dc.identifier.endpage234
dc.identifier.issn0344-0338
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage227
dc.identifier.urihttps://dx.doi.org/10.1016/j.prp.2016.12.010
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3632
dc.identifier.volume213
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofPathology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectGATA3
dc.subjectImmunohistochemistry
dc.subjectBreast Carcinoma
dc.subjectSpecial Subtypes
dc.subjectHistopathologic Findings
dc.subjectPrognosis
dc.titleGATA3 expression and its relationship with clinicopathological parameters in invasive breast carcinomas
dc.typeArticle

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