Short-term results of platelet-rich plasma in the treatment of chronic anal fissure: Randomized controlled clinical study

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dc.authorid0000-0003-0889-9586
dc.contributor.authorYılmaz, Gökhan
dc.contributor.authorTanrıkulu, Yusuf
dc.date.accessioned2021-04-06T08:31:47Z
dc.date.available2021-04-06T08:31:47Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBackground: Anal fissure is one of the most common benign anal disorders, and medical treatments play an important role in its management.Objective: The purpose of this study was to investigate the short-term effects and success of platelet-rich-plasma in the treatment of chronic anal fissure.Design: The study is a two parallel-group, randomized, controlled clinical trial.Settings: The study was carried out in two tertiary university hospitals.Patients: Forty-four-patients with chronic anal fissure were randomly assigned to platelet-rich-plasma treatment or control group. Presenting symptoms and pain scores were recorded on enrolment. The control patient self-administered topical glyceryl trinitrate. Platelet-rich-plasma was injected locally in the intervention group followed by self-administered glyceryl trinitrate.Main outcome measures: Primary outcome measure is a reduction in pain scores.Results: On day 10 and one month after treatment, the mean pain score was significantly lower in the platelet-rich-plasma patients than in the controls (p=0.005 and p<0.005, respectively). By one month after treatment, mean pain score declined by 5.7 points in the platelet-rich plasma-treated group compared with a 4.1 mean pain score decline in the control group (mean difference:1.6 points [95% confidence interval;0.3-2.9]).According to the repeated-measures analyses, Pain scores decreased in both groups, but the decrease in the treatment group was statistically higher than the control group (p<0.001).Complete epithelialization and recovery rates were significantly higher in the platelet-rich-plasma group than in controls at all follow-up times, with p-values ranging from 0.034 to<0.001.The observed difference in complete epithelialization after two months of treatment between the platelet-rich-plasma group and the control group was 56.2% with a 95% confidence interval of 14.03% to 98.4%.Limitations: This study was limited by its small sample size and long-term follow-up of the patients was not given.Conclusions: Platelet-rich-plasma reduced complaints and accelerated epithelialization and healing in patients with chronic anal fissures.
dc.identifier.citationYılmaz, G. ve Tanrıkulu, Y. (2021). Short-term results of platelet-rich plasma in the treatment of chronic anal fissure: Randomized controlled clinical study. Diseases of the Colon & Rectum, 64(6), 714-723. https://dx.doi.org/10.1097/DCR.0000000000001903
dc.identifier.doi10.1097/DCR.0000000000001903
dc.identifier.endpage723
dc.identifier.issn0012-3706
dc.identifier.issn1530-0358
dc.identifier.issue6
dc.identifier.scopusqualityQ1
dc.identifier.startpage714
dc.identifier.urihttps://dx.doi.org/10.1097/DCR.0000000000001903
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6701
dc.identifier.volume64
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott
dc.relation.ispartofDiseases of the Colon & Rectumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBotulinum Toxin
dc.subjectChronic Anal Fissure
dc.subjectLateral Internal Sphincterotomy
dc.subjectMedical Treatment
dc.subjectPlatelet Rich Plasma
dc.titleShort-term results of platelet-rich plasma in the treatment of chronic anal fissure: Randomized controlled clinical study
dc.typeArticle

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