Factors associated with nocturia-related quality of life in men with lower urinary tract symptoms and treated with tamsulosin oral controlled absorption system in a non-interventional study

Michel, Martin Christian; Schumacher, Helmut; Mehlburger, Ludwig; de la Rosette, Jean J. M. C. H.

Factors associated with nocturia-related quality of life in men with lower urinary tract symptoms and treated with tamsulosin oral controlled absorption system in a non-interventional study

dc.authorid	0000-0002-6308-1763
dc.contributor.author	Michel, Martin Christian
dc.contributor.author	Schumacher, Helmut
dc.contributor.author	Mehlburger, Ludwig
dc.contributor.author	de la Rosette, Jean J. M. C. H.
dc.date.accessioned	2020-07-27T11:43:58Z
dc.date.available	2020-07-27T11:43:58Z
dc.date.issued	2020
dc.department	İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstract	Nocturia impairs quality of life (QoL). We have performed a non-interventional study in which men with lower urinary tract symptoms (LUTS) were treated for at least 3 months with tamsulosin oral controlled absorption system (0.4 mg q.d.). Other than observing efficacy and tolerability of this drug formulation, the study was designed to explore the relative roles of number of nocturia episodes and of non-urological causes of nocturia on nocturia-related QoL at baseline and treatment-associated changes thereof. The study enrolled 5775 men seeking treatment of their LUTS. Tamsulosin improved LUTS, e.g. International Prostate Symptom Score from 19.5 +/- 5.9 to 10.1 +/- 4.9 (means +/- SD). This was associated by clinically meaningful improvements in the Nocturia QoL score (from 45 +/- 19 to 73 +/- 17 points) and other QoL scores. Number of nocturnal voids was the key driver of all QoL scores at baseline; change of number of nocturia episodes that of improvement of all QoL scores upon treatment. In contrast, non-urological causes of nocturia such as heart failure, diabetes, sleep apnea, fluid or alcohol intake or use of diuretics or hypnotics had only small if any effects on baseline QoL or treatment-associated improvements thereof. The observed effects of non-urological causes on QoL apparently were largely driven by their effect on number of nocturnal voids. These data further support the idea that improvement of nocturia may be an important treatment goal in male LUTS.
dc.description.sponsorship	German Research Foundation (DFG) Boehringer Ingelheim	en_US
dc.identifier.citation	Michel, M. C., Schumacher, H., Mehlburger, L. ve de la Rosette, J. J. M. C. H. (2020). Factors associated with nocturia-related quality of life in men with lower urinary tract symptoms and treated with tamsulosin oral controlled absorption system in a non-interventional study. Frontiers in Pharmacology, 11. https://dx.doi.org/10.3389/fphar.2020.00816
dc.identifier.doi	10.3389/fphar.2020.00816
dc.identifier.issn	1663-9812
dc.identifier.scopusquality	Q1
dc.identifier.uri	https://dx.doi.org/10.3389/fphar.2020.00816
dc.identifier.uri	https://hdl.handle.net/20.500.12511/5613
dc.identifier.volume	11
dc.identifier.wosquality	Q1
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.language.iso	en
dc.publisher	Frontiers Media S.A.
dc.relation.ispartof	Frontiers in Pharmacology	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	Attribution 4.0 International	*
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject	Male Lower Urinary Tract Symptoms
dc.subject	Nocturia
dc.subject	Quality of Life
dc.subject	Diabetes
dc.subject	Heart Failure
dc.title	Factors associated with nocturia-related quality of life in men with lower urinary tract symptoms and treated with tamsulosin oral controlled absorption system in a non-interventional study
dc.type	Article