Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: Association with neuroprotection of pyramidal cells

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dc.contributor.authorKaplan, Süleyman
dc.contributor.authorÖnger, Mehmet Emin
dc.contributor.authorAltunkaynak, Berrin Zühal
dc.contributor.authorElibol, Ebru
dc.contributor.authorDeniz, Ömür Gülsüm
dc.contributor.authorKarayiğit, Mehmet Önder
dc.contributor.authorYarım, Murat
dc.contributor.authorMarangoz, Cafer
dc.contributor.authorRa?betli, Murat Çetin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:50Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:50Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000427664300005
dc.descriptionPubMed ID: 29126816
dc.description.abstractThe aim of this study is to investigate the effects of spermine and the passive avoidance learning on hippocampus following transient cerebral ischemia in the chicks. The study is composed of the pure control (CG), sham (SG) and experimental groups (n = 20). Experimental groups (ischemia group, IG and ischemia-spermine group, ISG) were exposed to ischemia for 20 min whereas the SG was exposed to sham operation and CG group was not exposed to any operation. Passive avoidance learning (PAL) was applied to the half number of the subjects in each group. Both before and after 7 days from the ischemia, operated animals were taken to PAL and then they were sacrificed. Total numbers of neurons in the hippocampus were stereologically estimated using Cresyl violet stained sections. We detected that number of neurons was increased following PAL and especially spermine treatment. According to our results, we suggested that spermine may reduce the deleterious effects of the ischemia by causing to increase in the neuronal number and so, it may be slightly supportive to the PAL.
dc.description.sponsorshipOndokuz Mayis University [PYO. TIP. 1901.09.015]en_US
dc.description.sponsorshipThe Animal Ethics Committee of Yuzuncu Yil University approved the protocol and appropriate measures were taken to minimize pain or discomfort of the animals by our study group. The experimental part of this study and stereological examination was performed at Ondokuz Mayis University, Department of Histology and Embryology. This study was supported by Ondokuz Mayis University, (PYO. TIP. 1901.09.015).en_US
dc.identifier.citationKaplan, S., Önger, M. E., Altunkaynak, B. Z., Elibol, E., Deniz, Ö. G., Karayiğit, M. Ö. ... Ra?betli, M. Ç. (2018). Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: Association with neuroprotection of pyramidal cells. Journal of Chemical Neuroanatomy, 88, 41-45. https://dx.doi.org/10.1016/j.jchemneu.2017.11.006
dc.identifier.doi10.1016/j.jchemneu.2017.11.006
dc.identifier.endpage45
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.scopusqualityQ3
dc.identifier.startpage41
dc.identifier.urihttps://dx.doi.org/10.1016/j.jchemneu.2017.11.006
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2087
dc.identifier.volume88
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectIschemia
dc.subjectSpermine
dc.subjectHippocampus
dc.subjectLearning
dc.subjectStereology
dc.titleEffects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: Association with neuroprotection of pyramidal cells
dc.typeArticle

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