Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia

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dc.authorid0000-0002-3131-442X
dc.authorid0000-0001-8945-2385
dc.authorid0000-0001-8022-7325
dc.contributor.authorAydın, Selda
dc.contributor.authorMert, Ali
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorAl Maslamani, Muna
dc.contributor.authorRahimi, Bilal Ahmad
dc.contributor.authorAyoade, Folusakin
dc.contributor.authorEl-Kholy, Amani
dc.contributor.authorBelitova, Maya
dc.contributor.authorErdem, Hakan
dc.date.accessioned2024-01-19T11:53:37Z
dc.date.available2024-01-19T11:53:37Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: During the COVID pandemic, research has shown an increase in candidemia cases following severe COVID infection and the identification of risk factors associated with candidemia. However, there is a lack of studies that specifically explore clinical outcomes and mortality rates related to candidemia after COVID infection.Objectives: The aim of this international study was to evaluate the clinical outcomes and identify factors influencing mortality in patients who developed candidemia during their COVID infection.Patients/Methods: This study included adult patients (18 years of age or older) admitted to the intensive care unit (ICU) and diagnosed with COVID-associated candidemia (CAC). The research was conducted through ID-IRI network and in collaboration with 34 medical centres across 18 countries retrospectively, spanning from the beginning of the COVID pandemic until December 2021.Results: A total of 293 patients diagnosed with CAC were included. The median age of the patients was 67, and 63% of them were male. The most common Candida species detected was C. albicans. The crude 30-day mortality rate was recorded at 62.4%. The logistic regression analysis identified several factors significantly impacting mortality, including age (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.02-1.07, p < .0005), SOFA score (OR 1.307, 95% CI 1.17-1.45, p < .0005), invasive mechanical ventilation (OR 7.95, 95% CI 1.44-43.83, p < .017) and duration of mechanical ventilation (OR 0.98, 95% CI 0.96-0.99, p < .020).Conclusions: By recognising these prognostic factors, medical professionals can customise their treatment approaches to offer more targeted care, leading to improved patient outcomes and higher survival rates for individuals with COVID-associated candidemia.
dc.identifier.citationAydın, S., Mert, A., Yılmaz, M., Al Maslamani, M., Rahimi, B. A., Ayoade, F. ... Erdem, H. (2024). Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia. Mycoses, 67(1). https://dx.doi.org/10.1111/myc.13687
dc.identifier.doi10.1111/myc.13687
dc.identifier.issn0933-7407
dc.identifier.issn1439-0507
dc.identifier.issue1
dc.identifier.pmid38214425
dc.identifier.scopus2-s2.0-85181705067
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1111/myc.13687
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12178
dc.identifier.volume67
dc.identifier.wos001135697400001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Selda
dc.institutionauthorMert, Ali
dc.institutionauthorYılmaz, Mesut
dc.institutionauthorMadendere, Berk
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMycosesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCandidemia
dc.subjectCOVID-19
dc.subjectCOVID-19-Associated Candidemia
dc.subjectIntensive Care Unit
dc.subjectMortality
dc.titleUnderstanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia
dc.typeArticle

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