Prognostic factors and intensive care outcome in post-transplant phase of hematopoietic stem cell transplantation intensive care outcome in hematopoietic stem cell transplantation

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dc.authorid0000-0003-1508-2822
dc.authorid0000-0001-6826-7818
dc.authorid0000-0002-5715-8138
dc.authorid0000-0001-6587-8103
dc.authorid0000-0003-1237-8281
dc.authorid0000-0002-3385-8359
dc.authorid0000-0002-2035-9462
dc.authorid0000-0001-9636-4113
dc.contributor.authorMutlu, Yaşa Gül
dc.contributor.authorBalık Aydın, Berrin
dc.contributor.authorErdoğan, Cem
dc.contributor.authorKızılaslan, Deniz
dc.contributor.authorBeköz, Hüseyin Saffet
dc.contributor.authorGemici, Aliihsan
dc.contributor.authorKaynar, Leylagül
dc.contributor.authorSevindik, Ömür Gökmen
dc.date.accessioned2023-09-19T07:28:04Z
dc.date.available2023-09-19T07:28:04Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractIntroduction To identify new clinical and biologic parameters associated with short-term survival in allogeneic or autologous hematopoietic stem cell transplantation (HSCT) patients who were admitted to the intensive care unit (ICU) during their post-transplant period. Materials and methods 40 patients who were admitted to the ICU in our center during their post-transplant period were evaluated retrospectively between Jan 2014 - Jun 2021. Baseline patient characteristics before the transplant, reasons for ICU admissions, laboratory and clinical findings, supportive treatment in ICU and short-term survival were analyzed. Results We found 8.8% ICU admission rate in all patient group (n = 450). Mortality rate of the patients who were admitted to ICU was 75%. Invasive mechanic ventilation, need for vasopressor, heart rate was significantly different between survivor and non-survivor group (p = 0.001, p = 0.001, p = 0.004). Elevated INR was associated with poor survival on ICU (p = 0.033). APACHE II score was an independent predictor of ICU mortality (p = 0.045). Conclusion Despite the recent advances in transplant conditioning protocols, prophylaxis strategies and improvements of management in ICU, overall survival for HSCT patients in ICU is still poor. In this study INR level was described as a new prognostic factor in ICU for first time in the literature.
dc.identifier.citationMutlu, Y. G., Balık Aydın, B., Erdoğan, C., Kızılaslan, D., Beköz, H. S., Gemici, A. ... Sevindik, Ö. G. (2023). Prognostic factors and intensive care outcome in post-transplant phase of hematopoietic stem cell transplantation intensive care outcome in hematopoietic stem cell transplantation. Indian Journal of Hematology and Blood Transfusion, 39(2), 167-172. https://doi.org/10.1007/s12288-022-01575-5
dc.identifier.doi10.1007/s12288-022-01575-5
dc.identifier.endpage172
dc.identifier.issn0971-4502
dc.identifier.issn0974-0449
dc.identifier.issue2
dc.identifier.pmid37006979
dc.identifier.scopus2-s2.0-85139659508
dc.identifier.scopusqualityQ3
dc.identifier.startpage167
dc.identifier.urihttps://doi.org/10.1007/s12288-022-01575-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11455
dc.identifier.volume39
dc.identifier.wos000865918200001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMutlu, Yaşa Gül
dc.institutionauthorBalık Aydın, Berrin
dc.institutionauthorErdoğan, Cem
dc.institutionauthorKızılaslan, Deniz
dc.institutionauthorBeköz, Hüseyin Saffet
dc.institutionauthorGemici, Aliihsan
dc.institutionauthorKaynar, Leylagül
dc.institutionauthorSevindik, Ömür Gökmen
dc.language.isoen
dc.publisherSpringer India
dc.relation.ispartofIndian Journal of Hematology and Blood Transfusionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCritically Ill
dc.subjectMortality
dc.subjectTransplantation
dc.titlePrognostic factors and intensive care outcome in post-transplant phase of hematopoietic stem cell transplantation intensive care outcome in hematopoietic stem cell transplantation
dc.typeArticle

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