Isolated subclinical right ventricle systolic dysfunction in patients after liver transplantation

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dc.authorid0000-0003-2995-8792
dc.authorid0000-0002-0113-9907
dc.authorid0000-0001-7545-6318
dc.authorid0000-0002-4281-0867
dc.authorid0000-0001-7581-6424
dc.contributor.authorÇeliker Güler, Emel
dc.contributor.authorOmaygenç, Mehmet Onur
dc.contributor.authorNaki, Deniz Dilan
dc.contributor.authorYazar, Arzu
dc.contributor.authorKaraca, İbrahim Oğuz
dc.contributor.authorKorkut, Esin
dc.date.accessioned2023-04-14T07:44:44Z
dc.date.available2023-04-14T07:44:44Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractAlthough hemodynamic alterations in end-stage liver disease (ESLD) and its association with porto-pulmonary hypertension have been well-established, the long-term effects of ESLD on RV systolic function in patients without porto-pulmonary hypertension remain disregarded. Here we aimed to assess the long-term effect of ESLD on RV function and its relationship with the use of NSBBs and clinical, laboratory and imaging parameters in end-stage liver disease. The use of NSBBs is still controversial due to concerns about reduced cardiac contractility and the possibility of increased mortality. Thirty-four liver transplant recipients were included. Demographic characteristics, laboratory and baseline echocardiography measures were obtained. Patients were recalled for transthoracic echocardiographic evaluation after transplantation. Right ventricle dysfunction was identified by having at least one value below the reference levels of RV S', or TAPSE. Isolated subclinical RV dysfunction was observed at 20.6% of the sample population. The present study demonstrates hemodynamic circulation in cirrhosis and increased preload and afterload might have long-term effects on RV function, even the lack of porto-pulmonary hypertension. These findings underline the significance of cardiac function follow-up in cirrhotic patients after transplantation. In this study, patients treated with propranolol seemed to have better RV function and less gastrointestinal bleeding. We speculated that preoperative propranolol treatment might help preserve RV function by providing RAS suppression, improving endothelial function and hyperdynamic circulation seen in ESLD. This potential protective relationship between the use of propranolol and RV function might improve mortality or graft-failure during OLT and after liver transplantation in patients with cirrhosis.
dc.identifier.citationÇeliker Güler, E., Omaygenç, M. O., Naki, D. D., Yazar, A., Karaca, İ. O. ve Korkut, E. (2023). Isolated subclinical right ventricle systolic dysfunction in patients after liver transplantation. Journal of Clinical Medicine, 12(6). https://dx.doi.org/10.3390/jcm12062289
dc.identifier.doi10.3390/jcm12062289
dc.identifier.issn2077-0383
dc.identifier.issue6
dc.identifier.pmid36983288
dc.identifier.scopus2-s2.0-85151394260
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3390/jcm12062289
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10864
dc.identifier.volume12
dc.identifier.wos000955502600001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOmaygenç, Mehmet Onur
dc.institutionauthorNaki, Deniz Dilan
dc.institutionauthorYazar, Arzu
dc.institutionauthorKaraca, İbrahim Oğuz
dc.institutionauthorKorkut, Esin
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofJournal of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectEnd-Stage Chronic Liver Disease
dc.subjectLiver Transplantation
dc.subjectHeart Failure
dc.subjectRight Ventricle Function
dc.subjectPropranolol
dc.titleIsolated subclinical right ventricle systolic dysfunction in patients after liver transplantation
dc.typeArticle

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