Examination of age-dependent effects of fetal ethanol exposure on behavior, hippocampal cell counts, and doublecortin immunoreactivity in rats

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dc.authorid0000-0001-6494-8923
dc.contributor.authorElibol-Can, Birsen
dc.contributor.authorDursun, İlknur
dc.contributor.authorTelkes, İlknur
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorCanan, Sinan
dc.contributor.authorJakubowska-Doğru, Ewa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:49Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:49Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000333998100002
dc.descriptionPubMed ID: 24302592
dc.description.abstractEthanol is known as a potent teratogen having adverse effects on brain and behavior. However, some of the behavioral deficits caused by fetal alcohol exposure and well expressed in juveniles ameliorate with maturation may suggest some kind of functional recovery occurring during postnatal development. The aim of this study was to reexamine age-dependent behavioral impairments in fetal-alcohol rats and to investigate the changes in neurogenesis and gross morphology of the hippocampus during a protracted postnatal period searching for developmental deficits and/or delays that would correlate with behavioral impairments in juveniles and for potential compensatory processes responsible for their amelioration in adults. Ethanol was delivered to the pregnant dams by intragastric intubation throughout 7-21 gestation days at daily dose of 6 g/kg. Isocaloric intubation and intact control groups were included. Locomotor activity, anxiety, and spatial learning tasks were applied to juvenile and young-adult rats from all groups. Unbiased stereological estimates of hippocampal volumes, the total number of pyramidal and granular cells, and double cortin expressing neurons were carried out for postnatal days (PDs) PD1, PD10, PD30, and PD60. Alcohol insult during second trimester equivalent caused significant deficits in the spatial learning in juvenile rats; however, its effect on hippocampal morphology was limited to a marginally lower number of granular cells in dentate gyrus (DG) on PD30. Thus, initial behavioral deficits and the following functional recovery in fetal-alcohol subjects may be due to more subtle plastic changes within the hippocampal formation but also in other structures of the extended hippocampal circuit. Further investigation is required. (c) 2013 Wiley Periodicals, Inc. Develop Neurobiol 74: 498-513, 2014
dc.description.sponsorshipMETU Scientific Research Fund; Turkish Scientific and Technical Council (TUBITAK) [SBAG-107S069]; TUBITAK PhD scholarshipen_US
dc.description.sponsorshipTurkish Scientific and Technical Council (TUBITAK) [SBAG-107S069]en_US
dc.description.sponsorshipContract grant sponsor: METU Scientific Research Fund.; Contract grant sponsor: Turkish Scientific and Technical Council (TUBITAK); contract grant number: SBAG-107S069 (to E.J.D.).; Contract grant sponsor: TUBITAK PhD scholarship (to B.E.C.).en_US
dc.identifier.citationElibol-Can, B., Dursun, İ., Telkes, İ., Kılıç, E., Canan, S. ve Jakubowska-Doğru, E. (2014). Examination of age-dependent effects of fetal ethanol exposure on behavior, hippocampal cell counts, and doublecortin immunoreactivity in rats. Developmental Neurobiology, 74(5), 498-513. https://dx.doi.org/10.1002/dneu.22143
dc.identifier.doi10.1002/dneu.22143
dc.identifier.endpage513
dc.identifier.issn1932-8451
dc.identifier.issn1932-846X
dc.identifier.issue5
dc.identifier.scopusqualityQ1
dc.identifier.startpage498
dc.identifier.urihttps://dx.doi.org/10.1002/dneu.22143
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2291
dc.identifier.volume74
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofDevelopmental Neurobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/107S069
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPostnatal Hippocampal Development
dc.subjectDoublecortin Immunoreactivity
dc.subjectRat
dc.subjectFetal Alcohol
dc.subjectUnbiased Stereology
dc.titleExamination of age-dependent effects of fetal ethanol exposure on behavior, hippocampal cell counts, and doublecortin immunoreactivity in rats
dc.typeArticle

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