Short-term efficacy of ORS formulation and propranolol regimen in children with POTS

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dc.contributor.authorYozgat, Yılmaz
dc.contributor.authorOtcu Temur, Hafize
dc.contributor.authorÇoban, Şenay
dc.contributor.authorÖner, Taliha
dc.contributor.authorKaraarslan, Utku
dc.contributor.authorYozgat, Can Yılmaz
dc.contributor.authorKaradeniz, Cem
dc.contributor.authorErgör, Serap Nur
dc.contributor.authorErenberk, Ufuk
dc.date.accessioned2020-09-03T08:10:08Z
dc.date.available2020-09-03T08:10:08Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: To evaluate the short-term effectiveness of reduced-osmolarity oral rehydration salt formulation (ORS) and propranolol in children diagnosed with postural orthostatic tachycardia syndrome (POTS) in head-up tilt testing (HUTT).Methods: Children were admitted with symptoms of orthostatic intolerance (OI) occurring in a standing position and disappearing in the supine position. Patients with heart rate increments of >= 40 bpm and symptoms of OI constituted the pediatric POTS group in HUTT. A total of 70 pediatric patients with POTS were included in the study. POTS patients were divided into two groups based on whether they were prescribed reduced-osmolarity ORS and propranolol or not. The study group comprised patients on a regimen of reduced-osmolarity ORS and propranolol (n = 34), while the control group comprised patients who were not prescribed any medication (n = 36). The frequency of symptoms and standardized symptom scores were analyzed before and after 3 months of treatment in both groups.Results: The post-treatment frequency of syncopal attacks was significantly reduced in both groups (P < 0.01 for both groups), but the post-treatment standardized symptom scores were significantly reduced in the pediatric study group compared with the control group (P < 0.01).Conclusion: The frequency of syncopal attacks was significantly reduced and the symptom scores for OI were improved in the study group. The improvement in OI symptom scores was better in the treatment group than in the control group. The control group symptoms persisted and caused extreme difficulty in their daily activities. In view of its clinical efficacy, we strongly advocate the use of combined treatment of reduced-osmolarity ORS and low-dose propranolol in pediatric patients with POTS. (C) 2020 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
dc.identifier.citationYozgat, Y., Otcu Temur, H., Çoban, Ş., Öner, T., Karaarslan, U. ve Yozgat, C. Y. (2020). Short-term efficacy of ORS formulation and propranolol regimen in children with POTS. Archives de Pediatrie, 27(6), 328-332. https://dx.doi.org/10.1016/j.arcped.2020.06.001
dc.identifier.doi10.1016/j.arcped.2020.06.001
dc.identifier.endpage332
dc.identifier.issn0929-693X
dc.identifier.issn1769-664X
dc.identifier.issue6
dc.identifier.scopusqualityQ3
dc.identifier.startpage328
dc.identifier.urihttps://dx.doi.org/10.1016/j.arcped.2020.06.001
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5768
dc.identifier.volume27
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofArchives de Pediatrieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectOral Rehydration Salt
dc.subjectOrthostatic Intolerance
dc.subjectPostural Orthostatic Tachycardia Syndrome
dc.subjectPropranolol
dc.titleShort-term efficacy of ORS formulation and propranolol regimen in children with POTS
dc.typeArticle

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