Adrenergic modulation of melanocortin pathway by hunger signals

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dc.authorid0000-0003-2075-7724
dc.contributor.authorSayar Atasoy, Nilüfer
dc.contributor.authorLaule, Connor
dc.contributor.authorAklan, İltan
dc.contributor.authorKim, Hyojin
dc.contributor.authorYavuz, Yavuz
dc.contributor.authorAteş, Tayfun
dc.contributor.authorÇoban, İlknur
dc.contributor.authorKöksalar Alkan, Fulya
dc.contributor.authorRysted, Jacob
dc.contributor.authorDavis, Debbie
dc.contributor.authorSingh, Uday
dc.contributor.authorAlp, Muhammed İkbal
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorCui, Huxing
dc.contributor.authorAtasoy, Deniz
dc.date.accessioned2023-10-27T08:08:44Z
dc.date.available2023-10-27T08:08:44Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstractNorepinephrine (NE) is a well-known appetite regulator, and the nor/adrenergic system is targeted by several anti-obesity drugs. To better understand the circuitry underlying adrenergic appetite control, here we investigated the paraventricular hypothalamic nucleus (PVN), a key brain region that integrates energy signals and receives dense nor/adrenergic input, using a mouse model. We found that PVN NE level increases with signals of energy deficit and decreases with food access. This pattern is recapitulated by the innervating catecholaminergic axon terminals originating from NTSTH-neurons. Optogenetic activation of rostral-NTSTH ? PVN projection elicited strong motivation to eat comparable to overnight fasting whereas its inhibition attenuated both fasting-induced & hypoglycemic feeding. We found that NTSTH-axons functionally targeted PVNMC4R-neurons by predominantly inhibiting them, in part, through ?1-AR mediated potentiation of GABA release from ARCAgRP presynaptic terminals. Furthermore, glucoprivation suppressed PVNMC4R activity, which was required for hypoglycemic feeding response. These results define an ascending nor/adrenergic circuit, NTSTH ? PVNMC4R, that conveys peripheral hunger signals to melanocortin pathway.
dc.description.sponsorshipNational Institutes of Healthen_US
dc.identifier.citationSayar Atasoy, N., Laule, C., Aklan, İ., Kim, H., Yavuz, Y., Ateş, T. ... Atasoy, D. (2023). Adrenergic modulation of melanocortin pathway by hunger signals. Nature Communications, 14(1). https://dx.doi.org/10.1038/s41467-023-42362-8
dc.identifier.doi10.1038/s41467-023-42362-8
dc.identifier.issn2041-1723
dc.identifier.issue1
dc.identifier.pmid37857606
dc.identifier.scopus2-s2.0-85174463545
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1038/s41467-023-42362-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11654
dc.identifier.volume14
dc.identifier.wos001100196000010en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlp, Muhammed İkbal
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofNature Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectMelanocortin Pathway
dc.subjectHunger Signals
dc.subjectAdrenergic Modulation
dc.titleAdrenergic modulation of melanocortin pathway by hunger signals
dc.typeArticle

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