How do children with drug-resistant epilepsy sleep? A clinical and video-PSG study

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dc.authorid0000-0003-1513-6149
dc.contributor.authorArhan, Ebru
dc.contributor.authorKoç Uçar, Habibe
dc.contributor.authorAydın, Kürşad
dc.contributor.authorLüleci Hirfano?lu, Tu?ba
dc.contributor.authorSerdaroğlu, Ayşe
dc.date.accessioned2021-02-11T06:50:49Z
dc.date.available2021-02-11T06:50:49Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractAim: The aim of this study was to assess sleep architecture and sleep problems among three homogenous groups of children including children with drug-resistant focal epilepsy, children with newly diagnosed, drug-naive focal epilepsy, and healthy children using overnight video-polysomnography (V-PSG) and a sleep questionnaire.Methods: We compared sleep architecture among 44 children with drug-resistant focal epilepsy, 41 children with newly diagnosed, drug naive focal epilepsy, and 36 healthy children. All children underwent an overnight V-PSG recording, and their parents completed the Children's Sleep Habits Questionnaire (CSHQ). Sleep recordings were scored according to the American Academy of Sleep Medicine criteria.Results: Compared with children with newly diagnosed epilepsy and healthy controls, children with drug-resistant epilepsy receiving antiepileptic treatment showed disturbed sleep architecture, a significant reduction in time in bed, total sleep time, sleep efficiency, NREM3%, REM%, and a significant increase in awakenings, wake after sleep onset, and periodic leg movement. Children with drug-naive, newly diagnosed focal epilepsy showed a statistically significant increase in sleep onset latency, rapid eye movement (REM) latency, N1%, awakenings, and a significant decrease in time in bed when compared with the controls. Children with drug-resistant epilepsy had the highest CSHQ total scores, while children with drug-naive, newly diagnosed focal epilepsy had higher scores than healthy children.Conclusion: This is one of the few polysomnographic studies adding to the limited research on the sleep macrostructure of children with drug-resistant epilepsy compared with children with drug-naive, newly diagnosed focal epilepsy and healthy children by obtaining objective measurements of sleep concurrently with a validated questionnaire. Children with drug-resistant epilepsy had a greater incidence of sleep disturbance on the basis of qualitative aspects and architecture of sleep than children with newly diagnosed epilepsy, suggesting the need for referral of children with drug-resistant epilepsy for overnight sleep evaluation in order to improve the clinical management and optimize therapeutic strategies.
dc.identifier.citationArhan, E., Koç Uçar, H., Aydın, K., Lüleci Hirfano?lu, T. ve Serdaroğlu, A. (2021). How do children with drug-resistant epilepsy sleep? A clinical and video-PSG study. Epilepsy and Behavior, 114. https://dx.doi.org/10.1016/j.yebeh.2020.107320
dc.identifier.doi10.1016/j.yebeh.2020.107320
dc.identifier.issn1525-5050
dc.identifier.issn1525-5069
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1016/j.yebeh.2020.107320
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6546
dc.identifier.volume114
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofEpilepsy and Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDrug-Resistant Epilepsy
dc.subjectSleep
dc.subjectPediatric Polysomnography
dc.subjectNewly Diagnosed Epilepsy
dc.titleHow do children with drug-resistant epilepsy sleep? A clinical and video-PSG study
dc.typeArticle

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