The assessment of maternal and umbilical cord neudesin levels in pregnancies with gestational diabetes mellitus

Basit Öğe Kaydı
dc.authorid0000-0002-1535-5934
dc.authorid0000-0002-4092-7316
dc.contributor.authorÇiler Eren, Elif
dc.contributor.authorKaya, Serdar
dc.contributor.authorArğun, Derya
dc.date.accessioned2023-01-12T11:21:24Z
dc.date.available2023-01-12T11:21:24Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractGestational diabetes mellitus (GDM) occurs due to the inability to adapt to physiologically observed changes in carbohydrate metabolism during pregnancy. Neudesin is a multi-functional secreted protein suggested to have a crucial regulator role in energy and carbohydrate metabolism. This study aimed to evaluate maternal serum and umbilical cord neudesin levels in pregnancies with GDM. Twenty-four singleton pregnancies with GDM were compared with gestational age-matched 23 uncomplicated pregnancies in this cross-sectional study. In comparison to the control group, significantly higher maternal serum and umbilical cord neudesin levels were observed in pregnancies with GDM (p <.001). Maternal serum and umbilical cord neudesin levels were also significantly positively correlated with maternal serum insulin levels and HOMA-IR values in the study group (p <.001). Neudesin, with its regulator role in carbohydrate metabolism, may be a contributing factor in the pathophysiology of GDM and may be a target of strategies for the prevention and treatment of GDM.Impact statementWhat is already known on this subject? Progressive changes in carbohydrate metabolism occur in normal pregnancy to provide continuous nutritional supply to the developing foetus and pregnant woman. When these progressive metabolic changes cannot be compensated, gestational diabetes mellitus (GDM) occurs. What the results of this study add? This is the first study to provide information about maternal serum and umbilical cord neudesin levels in pregnancies with GDM. This study observed that the serum levels of neudesin, which is suggested to have a regulator role in carbohydrate metabolism, were increased in pregnant women with GDM. What the implications are of these findings for clinical practice and/or future research? Neudesin may contribute to impaired carbohydrate metabolism in pregnancies with GDM and can be the subject of further studies on the prevention and treatment of GDM.
dc.identifier.citationÇiler Eren, E., Kaya, S. ve Arğun, D. (2022). The assessment of maternal and umbilical cord neudesin levels in pregnancies with gestational diabetes mellitus. Journal of Obstetrics and Gynaecology, 42(7), 2941-2945. https://dx.doi.org/10.1080/01443615.2022.2114328
dc.identifier.doi10.1080/01443615.2022.2114328
dc.identifier.endpage2945
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue7
dc.identifier.pmid36037070
dc.identifier.scopus2-s2.0-85136891897
dc.identifier.scopusqualityQ3
dc.identifier.startpage2941
dc.identifier.urihttps://dx.doi.org/10.1080/01443615.2022.2114328
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10295
dc.identifier.volume42
dc.identifier.wos000847312900001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇiler Eren, Elif
dc.institutionauthorKaya, Serdar
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectNeudesin
dc.subjectGestational Diabetes Mellitus
dc.subjectCarbohydrate Metabolism
dc.subjectInsulin Resistance
dc.subjectUmbilical Cord Neudesin Levels
dc.titleThe assessment of maternal and umbilical cord neudesin levels in pregnancies with gestational diabetes mellitus
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Eren-Eliif-2022.pdf
Boyut:
433.87 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu